Revealing static and dynamic modular architecture of the eukaryotic protein interaction network

Kakajan Komurov, Michael White

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

In an effort to understand the dynamic organization of the protein interaction network and its role in the regulation of cell behavior, positioning of proteins into specific network localities was studied with respect to their expression dynamics. First, we find that constitutively expressed and dynamically co-regulated proteins cluster in distinct functionally specialized network neighborhoods to form static and dynamic functional modules, respectively. Then, we show that whereas dynamic modules are mainly responsible for condition-dependent regulation of cell behavior, static modules provide robustness to the cell against genetic perturbations or protein expression noise, and therefore may act as buffers of evolutionary as well as population variations in cell behavior. Observations in this study refine the previously proposed model of dynamic modularity in the protein interaction network, and propose a link between the evolution of gene expression regulation and biological robustness.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalMolecular Systems Biology
Volume3
DOIs
StatePublished - 2007

Fingerprint

Protein Interaction Maps
Protein Interaction Networks
Proteins
Cell
Protein
proteins
Module
cells
Gene expression regulation
Cells
gene expression regulation
Robustness
Gene Expression Regulation
dynamic models
Noise
Buffers
Modularity
buffers
Locality
protein synthesis

Keywords

  • Dynamic modularity
  • Network robustness
  • Protein interaction networks

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics
  • Information Systems
  • Applied Mathematics

Cite this

Revealing static and dynamic modular architecture of the eukaryotic protein interaction network. / Komurov, Kakajan; White, Michael.

In: Molecular Systems Biology, Vol. 3, 2007, p. 1-11.

Research output: Contribution to journalArticle

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