TY - JOUR
T1 - Reversal of Nitrate Tolerance with N-Acetylcysteine
AU - Bertel, O.
AU - Noll, G.
AU - Marx, B. E.
AU - Packer, M.
AU - Hillis, L. D.
PY - 1988/3/10
Y1 - 1988/3/10
N2 - To the Editor: The two excellent studies on the development and reversal of nitrate tolerance, by Packer et al.1 and May et al.2 (Sept. 24 issue), both conclude — even in their titles — that N-acetylcysteine may reverse pharmacologic tolerance to nitroglycerin. We doubt, however, whether this conclusion can be supported by the published results. Both papers present evidence for the enhancement of nitrate effects in tolerant subjects, but the relative magnitude of N-acetylcysteine effects at the beginning of nitrate therapy and after the development of tolerance has not been investigated. Because the same interaction between N-acetylcysteine.
AB - To the Editor: The two excellent studies on the development and reversal of nitrate tolerance, by Packer et al.1 and May et al.2 (Sept. 24 issue), both conclude — even in their titles — that N-acetylcysteine may reverse pharmacologic tolerance to nitroglycerin. We doubt, however, whether this conclusion can be supported by the published results. Both papers present evidence for the enhancement of nitrate effects in tolerant subjects, but the relative magnitude of N-acetylcysteine effects at the beginning of nitrate therapy and after the development of tolerance has not been investigated. Because the same interaction between N-acetylcysteine.
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U2 - 10.1056/NEJM198803103181012
DO - 10.1056/NEJM198803103181012
M3 - Letter
C2 - 3125433
AN - SCOPUS:0023841058
SN - 0028-4793
VL - 318
SP - 638
EP - 639
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 10
ER -