Reversal of pigment gallstone disease in a canine model

L. G. Dawes, D. L. Nahrwold, S. I. Roth, Robert V Rege

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Unlike dietary-induced cholesterol gallstones, which may disappear spontaneously when the lithogenic diet is withdrawn, little is known about the natural history of pigment gallstones. We examined whether pigment gallstone disease, which can be uniformly induced in the dog by six weeks of a methionine-deficient diet, can be reversed by return to normal diet. As previously reported, all dogs develop pigment gallstones as well as significant increases in biliary total calcium, free ionized calcium, and cholesterol concentrations after six weeks of a lithogenic diet. These changes are accompanied by a significant increase in the concentration of unconjugated bile salts in bile. In addition, histologic changes in the gallbladder wall occur that are consistent with a moderate degree of chronic cholecystitis. This study clearly demonstrates that return to a normal diet for six weeks allows bile composition to normalize, gallstones to disappear in 50% of dogs, and gallbladder histologic changes to return toward normal. Thus, it would appear that pigment gallstone disease in this model may be reversible, at least early during its course. Although the relevance of these findings to pigment gallstones in humans must be established, the potential for nonoperative treatment of pigment gallstones should not be discounted.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalArchives of Surgery
Volume124
Issue number4
StatePublished - 1989

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Gallstones
Canidae
Diet
Dogs
Gallbladder
Bile
Calcium
Dietary Cholesterol
Cholecystitis
Natural History
Bile Acids and Salts
Methionine
Cholesterol

ASJC Scopus subject areas

  • Surgery

Cite this

Dawes, L. G., Nahrwold, D. L., Roth, S. I., & Rege, R. V. (1989). Reversal of pigment gallstone disease in a canine model. Archives of Surgery, 124(4), 463-466.

Reversal of pigment gallstone disease in a canine model. / Dawes, L. G.; Nahrwold, D. L.; Roth, S. I.; Rege, Robert V.

In: Archives of Surgery, Vol. 124, No. 4, 1989, p. 463-466.

Research output: Contribution to journalArticle

Dawes, LG, Nahrwold, DL, Roth, SI & Rege, RV 1989, 'Reversal of pigment gallstone disease in a canine model', Archives of Surgery, vol. 124, no. 4, pp. 463-466.
Dawes LG, Nahrwold DL, Roth SI, Rege RV. Reversal of pigment gallstone disease in a canine model. Archives of Surgery. 1989;124(4):463-466.
Dawes, L. G. ; Nahrwold, D. L. ; Roth, S. I. ; Rege, Robert V. / Reversal of pigment gallstone disease in a canine model. In: Archives of Surgery. 1989 ; Vol. 124, No. 4. pp. 463-466.
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