TY - JOUR
T1 - Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells
AU - Schneider, Jay W.
AU - Gu, Wei
AU - Zhu, Liang
AU - Mahdavi, Vijak
AU - Nadal-Ginard, Bernardo
PY - 1994
Y1 - 1994
N2 - The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.
AB - The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb-/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-/- myotubes.
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U2 - 10.1126/science.8197461
DO - 10.1126/science.8197461
M3 - Article
C2 - 8197461
AN - SCOPUS:0028339957
SN - 0036-8075
VL - 264
SP - 1467
EP - 1471
JO - Science
JF - Science
IS - 5164
ER -