Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells

Jay W. Schneider, Wei Gu, Liang Zhu, Vijak Mahdavi, Bernardo Nadal-Ginard

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Abstract

The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb-/-) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb-1- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb-1- myotubes.

Original languageEnglish (US)
Pages (from-to)1467-1471
Number of pages5
JournalScience
Volume264
Issue number5164
Publication statusPublished - Jun 3 1994

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Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., & Nadal-Ginard, B. (1994). Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science, 264(5164), 1467-1471.