TY - JOUR
T1 - Reverse Replay of Hippocampal Place Cells Is Uniquely Modulated by Changing Reward
AU - Ambrose, R. Ellen
AU - Pfeiffer, Brad E.
AU - Foster, David J.
N1 - Funding Information:
The authors thank the Johns Hopkins Bloomberg School of Public Health Statistics Consulting Center for help with generalized linear mixed models. This work was supported by The McKnight Endowment Fund for Neuroscience (D.J.F.) and National Institute of Mental Health grants R01MH085823 (D.J.F.) and R01MH103325 (D.J.F.).
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/9/7
Y1 - 2016/9/7
N2 - Hippocampal replays are episodes of sequential place cell activity during sharp-wave ripple oscillations (SWRs). Conflicting hypotheses implicate awake replay in learning from reward and in memory retrieval for decision making. Further, awake replays can be forward, in the same order as experienced, or reverse, in the opposite order. However, while the presence or absence of reward has been reported to modulate SWR rate, the effect of reward changes on replay, and on replay direction in particular, has not been examined. Here we report divergence in the response of forward and reverse replays to changing reward. While both classes of replays were observed at reward locations, only reverse replays increased their rate at increased reward or decreased their rate at decreased reward, while forward replays were unchanged. These data demonstrate a unique relationship between reverse replay and reward processing and point to a functional distinction between different directions of replay. Video Abstract
AB - Hippocampal replays are episodes of sequential place cell activity during sharp-wave ripple oscillations (SWRs). Conflicting hypotheses implicate awake replay in learning from reward and in memory retrieval for decision making. Further, awake replays can be forward, in the same order as experienced, or reverse, in the opposite order. However, while the presence or absence of reward has been reported to modulate SWR rate, the effect of reward changes on replay, and on replay direction in particular, has not been examined. Here we report divergence in the response of forward and reverse replays to changing reward. While both classes of replays were observed at reward locations, only reverse replays increased their rate at increased reward or decreased their rate at decreased reward, while forward replays were unchanged. These data demonstrate a unique relationship between reverse replay and reward processing and point to a functional distinction between different directions of replay. Video Abstract
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U2 - 10.1016/j.neuron.2016.07.047
DO - 10.1016/j.neuron.2016.07.047
M3 - Article
C2 - 27568518
AN - SCOPUS:84995511587
SN - 0896-6273
VL - 91
SP - 1124
EP - 1136
JO - Neuron
JF - Neuron
IS - 5
ER -