Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation

Qiong A. Wang, Anying Song, Wanze Chen, Petra C. Schwalie, Fang Zhang, Lavanya Vishvanath, Lei Jiang, Risheng Ye, Mengle Shao, Caroline Tao, Rana K Gupta, Bart Deplancke, Philipp E Scherer

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. Adipocytes in the mammary gland disappear during lactation. Wang et al. show that these mammary adipocytes fully de-differentiate into preadipocytes during lactation and readily re-differentiate during involution. The same adipocytes are therefore “recycled” over multiple rounds of pregnancies. De-differentiation constitutes a new possible fate for terminally differentiated adipocytes.

Original languageEnglish (US)
JournalCell Metabolism
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

White Adipocytes
Lactation
Adipocytes
Human Mammary Glands
Multiple Pregnancy
Weaning
Breast
Fibroblasts
Pregnancy
Reproduction
Adipose Tissue

Keywords

  • adipose tissue
  • de-differentiation
  • lactation
  • mammary gland
  • preadipocyte

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. / Wang, Qiong A.; Song, Anying; Chen, Wanze; Schwalie, Petra C.; Zhang, Fang; Vishvanath, Lavanya; Jiang, Lei; Ye, Risheng; Shao, Mengle; Tao, Caroline; Gupta, Rana K; Deplancke, Bart; Scherer, Philipp E.

In: Cell Metabolism, 01.01.2018.

Research output: Contribution to journalArticle

Wang, QA, Song, A, Chen, W, Schwalie, PC, Zhang, F, Vishvanath, L, Jiang, L, Ye, R, Shao, M, Tao, C, Gupta, RK, Deplancke, B & Scherer, PE 2018, 'Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation', Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.05.022
Wang, Qiong A. ; Song, Anying ; Chen, Wanze ; Schwalie, Petra C. ; Zhang, Fang ; Vishvanath, Lavanya ; Jiang, Lei ; Ye, Risheng ; Shao, Mengle ; Tao, Caroline ; Gupta, Rana K ; Deplancke, Bart ; Scherer, Philipp E. / Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. In: Cell Metabolism. 2018.
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