Abstract
Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. Adipocytes in the mammary gland disappear during lactation. Wang et al. show that these mammary adipocytes fully de-differentiate into preadipocytes during lactation and readily re-differentiate during involution. The same adipocytes are therefore “recycled” over multiple rounds of pregnancies. De-differentiation constitutes a new possible fate for terminally differentiated adipocytes.
| Original language | English (US) |
|---|---|
| Journal | Cell Metabolism |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- adipose tissue
- de-differentiation
- lactation
- mammary gland
- preadipocyte
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology
Cite this
Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation. / Wang, Qiong A.; Song, Anying; Chen, Wanze; Schwalie, Petra C.; Zhang, Fang; Vishvanath, Lavanya; Jiang, Lei; Ye, Risheng; Shao, Mengle; Tao, Caroline; Gupta, Rana K; Deplancke, Bart; Scherer, Philipp E.
In: Cell Metabolism, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation
AU - Wang, Qiong A.
AU - Song, Anying
AU - Chen, Wanze
AU - Schwalie, Petra C.
AU - Zhang, Fang
AU - Vishvanath, Lavanya
AU - Jiang, Lei
AU - Ye, Risheng
AU - Shao, Mengle
AU - Tao, Caroline
AU - Gupta, Rana K
AU - Deplancke, Bart
AU - Scherer, Philipp E
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. Adipocytes in the mammary gland disappear during lactation. Wang et al. show that these mammary adipocytes fully de-differentiate into preadipocytes during lactation and readily re-differentiate during involution. The same adipocytes are therefore “recycled” over multiple rounds of pregnancies. De-differentiation constitutes a new possible fate for terminally differentiated adipocytes.
AB - Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. Adipocytes in the mammary gland disappear during lactation. Wang et al. show that these mammary adipocytes fully de-differentiate into preadipocytes during lactation and readily re-differentiate during involution. The same adipocytes are therefore “recycled” over multiple rounds of pregnancies. De-differentiation constitutes a new possible fate for terminally differentiated adipocytes.
KW - adipose tissue
KW - de-differentiation
KW - lactation
KW - mammary gland
KW - preadipocyte
UR - http://www.scopus.com/inward/record.url?scp=85048159494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048159494&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2018.05.022
DO - 10.1016/j.cmet.2018.05.022
M3 - Article
C2 - 29909970
AN - SCOPUS:85048159494
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
ER -