@article{dabc888952b84aaba11711a4e10c4062,
title = "Reversible De-differentiation of Mature White Adipocytes into Preadipocyte-like Precursors during Lactation",
abstract = "Adipose tissue in the mammary gland undergoes dramatic remodeling during reproduction. Adipocytes are replaced by mammary alveolar structures during pregnancy and lactation, then reappear upon weaning. The fate of the original adipocytes during lactation and the developmental origin of the re-appearing adipocyte post involution are unclear. Here, we reveal that adipocytes in the mammary gland de-differentiate into Pdgfrα+ preadipocyte- and fibroblast-like cells during pregnancy and remain de-differentiated during lactation. Upon weaning, de-differentiated fibroblasts proliferate and re-differentiate into adipocytes. This cycle occurs over multiple pregnancies. These observations reveal the potential of terminally differentiated adipocytes to undergo repeated cycles of de-differentiation and re-differentiation in a physiological setting. Adipocytes in the mammary gland disappear during lactation. Wang et al. show that these mammary adipocytes fully de-differentiate into preadipocytes during lactation and readily re-differentiate during involution. The same adipocytes are therefore “recycled” over multiple rounds of pregnancies. De-differentiation constitutes a new possible fate for terminally differentiated adipocytes.",
keywords = "adipose tissue, de-differentiation, lactation, mammary gland, preadipocyte",
author = "Wang, {Qiong A.} and Anying Song and Wanze Chen and Schwalie, {Petra C.} and Fang Zhang and Lavanya Vishvanath and Lei Jiang and Risheng Ye and Mengle Shao and Caroline Tao and Gupta, {Rana K} and Bart Deplancke and Scherer, {Philipp E}",
note = "Funding Information: The authors were supported by U.S. NIH grants R01DK55758, R01DK099110, P01DK088761, and P01AG051459 to P.E.S.; K01DK107788 and R03HD095414 to Q.A.W.; and R01DK104789 to R.K.G. P.E.S was also supported by Cancer Prevention Research Institute of Texas grant RP140412 and an unrestricted grant from the Novo Nordisk Research Foundation. Q.A.W. was also supported by a City of Hope Shared Resources Pilot Program award. M.S. was supported by AHA postdoctoral fellowship 16POST26420136. We would like to thank members of the Histo Pathology Core at UTSW and Pathology Solid Tumor Core at COH, the Flow Cytometry Core at UTSW and Analytical Cytometry Core at COH, and City of Hope comprehensive cancer center. Funding Information: The authors were supported by U.S. NIH grants R01DK55758 , R01DK099110 , P01DK088761 , and P01AG051459 to P.E.S.; K01DK107788 and R03HD095414 to Q.A.W.; and R01DK104789 to R.K.G. P.E.S was also supported by Cancer Prevention Research Institute of Texas grant RP140412 and an unrestricted grant from the Novo Nordisk Research Foundation . Q.A.W. was also supported by a City of Hope Shared Resources Pilot Program award. M.S. was supported by AHA postdoctoral fellowship 16POST26420136 . We would like to thank members of the Histo Pathology Core at UTSW and Pathology Solid Tumor Core at COH, the Flow Cytometry Core at UTSW and Analytical Cytometry Core at COH, and City of Hope comprehensive cancer center. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = aug,
day = "7",
doi = "10.1016/j.cmet.2018.05.022",
language = "English (US)",
volume = "28",
pages = "282--288.e3",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}