Reversible idiopathic acute renal failure in children with primary nephrotic syndrome

Abdullah Sakarcan, Charles Timmons, Mouin G. Seikaly

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33 Citations (Scopus)

Abstract

We describe the clinical features of four pediatric patients (20 months to 10 years of age) in whom reversible idiopathic acute renal failure (RIARF) developed during the course of primary nephrotic syndrome (PNS). All patients had severe PNS and were in relapse at the onset of RIARF. This complication of PNS was preceded by primary peritonitis in three of four patients. Renal biopsy done in the early phases of RIARF showed tubular epithelial changes similar to those observed in acute tubular ischemia. All patients required dialysis. Recovery of renal function followed fluid removal in three of four patients. The RIARF lasted from 12 days to 1 year and was followed by complete recovery of renal function in all patients. We conclude that (1) RIARF is a potential complication in children with severe PNS, (2) RIARF is associated with primary ischemic renal tubular injury, and (3) recognition of the reversibility of this complication of PNS could alter long-term plans for management of renal failure in these patients. (J PEDIATR 1994;125:723-7).

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalThe Journal of Pediatrics
Volume125
Issue number5
StatePublished - Nov 1994

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Nephrotic Syndrome
Acute Kidney Injury
Kidney
Recovery of Function
Peritonitis
Renal Insufficiency
Dialysis
Ischemia
Pediatrics
Biopsy
Recurrence
Wounds and Injuries

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Reversible idiopathic acute renal failure in children with primary nephrotic syndrome. / Sakarcan, Abdullah; Timmons, Charles; Seikaly, Mouin G.

In: The Journal of Pediatrics, Vol. 125, No. 5, 11.1994, p. 723-727.

Research output: Contribution to journalArticle

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