Abstract
We describe the clinical features of four pediatric patients (20 months to 10 years of age) in whom reversible idiopathic acute renal failure (RIARF) developed during the course of primary nephrotic syndrome (PNS). All patients had severe PNS and were in relapse at the onset of RIARF. This complication of PNS was preceded by primary peritonitis in three of four patients. Renal biopsy done in the early phases of RIARF showed tubular epithelial changes similar to those observed in acute tubular ischemia. All patients required dialysis. Recovery of renal function followed fluid removal in three of four patients. The RIARF lasted from 12 days to 1 year and was followed by complete recovery of renal function in all patients. We conclude that (1) RIARF is a potential complication in children with severe PNS, (2) RIARF is associated with primary ischemic renal tubular injury, and (3) recognition of the reversibility of this complication of PNS could alter long-term plans for management of renal failure in these patients. (J PEDIATR 1994;125:723-7).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 723-727 |
| Number of pages | 5 |
| Journal | The Journal of Pediatrics |
| Volume | 125 |
| Issue number | 5 |
| State | Published - Nov 1994 |
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ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Reversible idiopathic acute renal failure in children with primary nephrotic syndrome. / Sakarcan, Abdullah; Timmons, Charles; Seikaly, Mouin G.
In: The Journal of Pediatrics, Vol. 125, No. 5, 11.1994, p. 723-727.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversible idiopathic acute renal failure in children with primary nephrotic syndrome
AU - Sakarcan, Abdullah
AU - Timmons, Charles
AU - Seikaly, Mouin G.
PY - 1994/11
Y1 - 1994/11
N2 - We describe the clinical features of four pediatric patients (20 months to 10 years of age) in whom reversible idiopathic acute renal failure (RIARF) developed during the course of primary nephrotic syndrome (PNS). All patients had severe PNS and were in relapse at the onset of RIARF. This complication of PNS was preceded by primary peritonitis in three of four patients. Renal biopsy done in the early phases of RIARF showed tubular epithelial changes similar to those observed in acute tubular ischemia. All patients required dialysis. Recovery of renal function followed fluid removal in three of four patients. The RIARF lasted from 12 days to 1 year and was followed by complete recovery of renal function in all patients. We conclude that (1) RIARF is a potential complication in children with severe PNS, (2) RIARF is associated with primary ischemic renal tubular injury, and (3) recognition of the reversibility of this complication of PNS could alter long-term plans for management of renal failure in these patients. (J PEDIATR 1994;125:723-7).
AB - We describe the clinical features of four pediatric patients (20 months to 10 years of age) in whom reversible idiopathic acute renal failure (RIARF) developed during the course of primary nephrotic syndrome (PNS). All patients had severe PNS and were in relapse at the onset of RIARF. This complication of PNS was preceded by primary peritonitis in three of four patients. Renal biopsy done in the early phases of RIARF showed tubular epithelial changes similar to those observed in acute tubular ischemia. All patients required dialysis. Recovery of renal function followed fluid removal in three of four patients. The RIARF lasted from 12 days to 1 year and was followed by complete recovery of renal function in all patients. We conclude that (1) RIARF is a potential complication in children with severe PNS, (2) RIARF is associated with primary ischemic renal tubular injury, and (3) recognition of the reversibility of this complication of PNS could alter long-term plans for management of renal failure in these patients. (J PEDIATR 1994;125:723-7).
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M3 - Article
C2 - 7965423
AN - SCOPUS:0028081789
VL - 125
SP - 723
EP - 727
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -