Reversible Monoubiquitination of PCNA: A Novel Slant on Regulating Translesion DNA Synthesis

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Abstract

Deubiquitination of monoubiquitinated proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cysteine proteases in eukaryotic cells. Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation.

Original languageEnglish (US)
Pages (from-to)150-152
Number of pages3
JournalMolecular Cell
Volume22
Issue number2
DOIs
StatePublished - Apr 21 2006

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Cysteine Proteases
Proliferating Cell Nuclear Antigen
Eukaryotic Cells
Radiation
DNA
Proteins
Deubiquitinating Enzymes

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Reversible Monoubiquitination of PCNA : A Novel Slant on Regulating Translesion DNA Synthesis. / Friedberg, Errol C.

In: Molecular Cell, Vol. 22, No. 2, 21.04.2006, p. 150-152.

Research output: Contribution to journalArticle

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