Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: Case report and literature review

Mike A. Singer, Christos Lazaridis, Sharon P. Nations, Gil I. Wolfe

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

A previously healthy 27-year-old woman developed a sub-acute myeloneuropathy after receiving nitrous oxide anesthesia for dental procedures. Neurologic evaluation revealed that she was vitamin B12 deficient due to underlying pernicious anemia. Discontinuation of nitrous oxide and supplementation with vitamin B12 resulted in dramatic clinical improvement, with near-complete normalization of her neurologic examination. This case and published reports reviewed here emphasize that favorable outcomes are possible following prompt recognition and treatment of vitamin B 12 deficiency.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalMuscle and Nerve
Volume37
Issue number1
DOIs
StatePublished - Jan 2008

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Pernicious Anemia
Nitrous Oxide
Vitamin B 12
Dental Anesthesia
Vitamin B 12 Deficiency
Neurologic Examination
Nervous System
Therapeutics

Keywords

  • Cobalamin
  • Deficiency
  • Nitrous oxide
  • Pernicious anemia
  • Vitamin B

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia : Case report and literature review. / Singer, Mike A.; Lazaridis, Christos; Nations, Sharon P.; Wolfe, Gil I.

In: Muscle and Nerve, Vol. 37, No. 1, 01.2008, p. 125-129.

Research output: Contribution to journalArticle

Singer, Mike A. ; Lazaridis, Christos ; Nations, Sharon P. ; Wolfe, Gil I. / Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia : Case report and literature review. In: Muscle and Nerve. 2008 ; Vol. 37, No. 1. pp. 125-129.
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