Review of inactive ingredients in antibiotic ear drops

G. Michael Wall, Onkar Singh, Leslie Lemke, Peter Roland

Research output: Contribution to journalReview article

Abstract

The authors review the relevant chemical and biological characteristics of inactive ingredients in antibiotic ear drop drug products. Although many of the older aminoglycoside-containing otic products are still used today, only some fluoroquinolone-containing ear drops, approved in the last decade, have been proven safe and effective according to current rigorous scientific standards, including ototoxicity testing of the formulations. Preservatives, antioxidants, surfactants, buffers, suspending and emulsifying agents, osmotic agents, viscosity modifiers, solvents, and penetration enhancers are reviewed with regard to their functional role in formulations, as well as their potential for ototoxicity.

Original languageEnglish (US)
Pages (from-to)E21
JournalEar, Nose and Throat Journal
Volume88
Issue number12
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Otorhinolaryngology

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  • Cite this

    Wall, G. M., Singh, O., Lemke, L., & Roland, P. (2009). Review of inactive ingredients in antibiotic ear drops. Ear, Nose and Throat Journal, 88(12), E21.