TY - JOUR
T1 - Review of inactive ingredients in antibiotic ear drops
AU - Wall, G. Michael
AU - Singh, Onkar
AU - Lemke, Leslie
AU - Roland, Peter
PY - 2009/12
Y1 - 2009/12
N2 - The authors review the relevant chemical and biological characteristics of inactive ingredients in antibiotic ear drop drug products. Although many of the older aminoglycoside-containing otic products are still used today, only some fluoroquinolone-containing ear drops, approved in the last decade, have been proven safe and effective according to current rigorous scientific standards, including ototoxicity testing of the formulations. Preservatives, antioxidants, surfactants, buffers, suspending and emulsifying agents, osmotic agents, viscosity modifiers, solvents, and penetration enhancers are reviewed with regard to their functional role in formulations, as well as their potential for ototoxicity.
AB - The authors review the relevant chemical and biological characteristics of inactive ingredients in antibiotic ear drop drug products. Although many of the older aminoglycoside-containing otic products are still used today, only some fluoroquinolone-containing ear drops, approved in the last decade, have been proven safe and effective according to current rigorous scientific standards, including ototoxicity testing of the formulations. Preservatives, antioxidants, surfactants, buffers, suspending and emulsifying agents, osmotic agents, viscosity modifiers, solvents, and penetration enhancers are reviewed with regard to their functional role in formulations, as well as their potential for ototoxicity.
UR - http://www.scopus.com/inward/record.url?scp=74049154441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049154441&partnerID=8YFLogxK
M3 - Review article
C2 - 20013666
AN - SCOPUS:74049154441
SN - 0145-5613
VL - 88
SP - E21
JO - Ear, Nose and Throat Journal
JF - Ear, Nose and Throat Journal
IS - 12
ER -