Review paper: Implications of the "cancer stem cell" hypothesis on murine models of colon cancer and colitis-associated cancer

M. J. Hynes, K. M. Huang, E. H. Huang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The use of murine models to investigate human diseases has been an invaluable tool. In the areas of inflammation and oncogenesis, such models have provided unique insights into pathogenesis and mechanisms to evaluate potential therapy. As such, one facet of these disease processes links inflammation and cancer. Inflammation is associated with at least 15% of the world's malignancies. One example of this relationship is documented in the association between colitis and colorectal cancer. To date, the precise molecular events linking inflammation and cancer remain unclear. A new paradigm that may bridge these processes includes the cancer stem cell hypothesis. In this review, murine models of colitis, colon cancer, and colitis-associated cancer are discussed in reference to the potential of this paradigm to clarify the relationship of these devastating diseases.

Original languageEnglish (US)
Pages (from-to)819-835
Number of pages17
JournalVeterinary pathology
Volume46
Issue number5
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Cancer
  • Cancer stem cells
  • Colitis
  • Murine models

ASJC Scopus subject areas

  • veterinary(all)

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