Review: Updates on novel therapies for metastatic renal cell carcinoma

Kevin D. Courtney, Toni K. Choueiri

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Metastatic renal cell carcinoma (RCC) poses one of the great therapeutic challenges in oncology. RCC is predominantly refractory to treatment with traditional cytotoxic chemotherapies, and until recently management options were limited to immunotherapy or palliative care. However, in the past few years we have experienced a sea change in the treatment of advanced RCC with the introduction of targeted therapies that derive their efficacy at least in part through alterations in tumor angiogenesis. The tyrosine kinase inhibitors sunitinib, pazopanib, and sorafenib, the monoclonal antibody bevacizumab (in combination with interferon-α), and the rapamycin analogs, temsirolimus and everolimus, are now approved agents in the United States for the treatment of metastatic RCC. Efforts to expand upon these successes include developing novel antiangiogenic agents, optimizing concomitant and sequential regimens, identifying predictors of response to specific treatments, and further dissecting the underlying molecular pathogenesis of RCC to reveal novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)209-219
Number of pages11
JournalTherapeutic Advances in Medical Oncology
Volume2
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • carcinoma
  • renal cell
  • therapeutics

ASJC Scopus subject areas

  • Oncology

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