Rewiring of posttranscriptional RNA regulons: Puf4p in fungi as an example

Huifeng Jiang, Xiaoxian Guo, Lin Xu, Zhenglong Gu

Research output: Contribution to journalArticlepeer-review

Abstract

It has been increasingly clear that changes in gene regulation play important roles in physiological and phenotypic evolution. Rewiring gene-regulatory networks, i.e., alteration of the gene-regulation system for different biological functions, has been demonstrated in various species. Posttranscriptional regulons have prominent roles in coordinating gene expression in a variety of eukaryotes. In this study, using Puf4p in fungi as an example, we demonstrate that posttranscriptional regulatory networks can also be rewired during evolution. Although Puf4p is highly conserved in fungi, targets of the posttranscriptional regulon are functionally diverse among known fungal species. In the Saccharomycotina subdivision, target genes of Puf4p mostly conduct function in the nucleolus; however, in the Pezizomycotina subdivision, they are enriched in the mitochondria. Furthermore, we demonstrate different regulation efficiencies of mitochondrial function by PUF proteins in different fungal clades. Our results indicate that rewiring of posttranscription regulatory networks may be an important way of generating genetic novelties in gene regulation during evolution.

Original languageEnglish (US)
Pages (from-to)2169-2176
Number of pages8
JournalMolecular biology and evolution
Volume29
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • evolution of gene regulation
  • posttranscriptional regulon
  • yeast

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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