RGS proteins provide biochemical control of agonist-evoked [Ca2+]i oscillations

Xiang Luo, Serguei Popov, Amal Kanti Bera, Thomas M. Wilkie, Shmuel Muallem

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Agonist-evoked [Ca2+]i oscillations have been considered a biophysical phenomenon reflecting the regulation of the IP3 receptor by [Ca2+]i. Here we show that [Ca2+]i oscillations are a biochemical phenomenon emanating from regulation of Ca2+ signaling by the regulators of G protein signaling (RGS) proteins. [Ca2+]i oscillations evoked by G protein-coupled receptors require the action of RGS proteins. Inhibition of endogenous RGS protein action disrupted agonist-evoked [Ca2+]i oscillations by a stepwise conversion to a sustained response. Based on these findings and the effect of mutant RGS proteins and anti-RGS protein antibodies on Ca2+ signaling, we propose that RGS proteins within the G protein-coupled receptor complexes provide a biochemical control of [Ca2+]i oscillations.

Original languageEnglish (US)
Pages (from-to)651-660
Number of pages10
JournalMolecular cell
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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