Rhabdomyolysis: A review, with emphasis on the pediatric population

Essam F. Elsayed, Robert F. Reilly

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA. It can result from a wide variety of disorders, such as trauma, exercise, medications and infection, but in the pediatric population, infection and inherited disorders are the most common causes of rhabdomyolysis. Approximately half of patients with rhabdomyolysis present with the triad of myalgias, weakness and dark urine. The clinical suspicion, especially in the setting of trauma or drugs, is supported by elevated creatinine kinase levels and confirmed by the measurement of myoglobin levels in serum or urine. Muscle biopsy and genetic testing should be performed if rhabdomyolysis is recurrent or metabolic myopathy is suspected. Early recognition is important to prevent AKI through the use of aggressive hydration. Prevention is important in patients with inherited forms, but novel therapies may be developed with the better understanding of the pathophysiology and genetics of rhabdomyolysis.

Original languageEnglish (US)
Pages (from-to)7-18
Number of pages12
JournalPediatric Nephrology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2010

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Keywords

  • Acute kidney injury
  • Genetic disorders
  • Myoglobin
  • Pediatric
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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