Rhabdomyolysis: A review, with emphasis on the pediatric population

Essam F. Elsayed, Robert F. Reilly

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Rhabdomyolysis is a common clinical syndrome and accounts for 7% of all cases of acute kidney injury (AKI) in the USA. It can result from a wide variety of disorders, such as trauma, exercise, medications and infection, but in the pediatric population, infection and inherited disorders are the most common causes of rhabdomyolysis. Approximately half of patients with rhabdomyolysis present with the triad of myalgias, weakness and dark urine. The clinical suspicion, especially in the setting of trauma or drugs, is supported by elevated creatinine kinase levels and confirmed by the measurement of myoglobin levels in serum or urine. Muscle biopsy and genetic testing should be performed if rhabdomyolysis is recurrent or metabolic myopathy is suspected. Early recognition is important to prevent AKI through the use of aggressive hydration. Prevention is important in patients with inherited forms, but novel therapies may be developed with the better understanding of the pathophysiology and genetics of rhabdomyolysis.

Original languageEnglish (US)
Pages (from-to)7-18
Number of pages12
JournalPediatric Nephrology
Volume25
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Rhabdomyolysis
Pediatrics
Population
Acute Kidney Injury
Urine
Myoglobin
Myalgia
Wounds and Injuries
Genetic Testing
Muscular Diseases
Infection
Creatinine
Phosphotransferases
Exercise
Biopsy
Muscles
Serum
Pharmaceutical Preparations

Keywords

  • Acute kidney injury
  • Genetic disorders
  • Myoglobin
  • Pediatric
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Rhabdomyolysis : A review, with emphasis on the pediatric population. / Elsayed, Essam F.; Reilly, Robert F.

In: Pediatric Nephrology, Vol. 25, No. 1, 01.2010, p. 7-18.

Research output: Contribution to journalArticle

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