Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation

Chen Zhu, Weiqing Xie, J R Falck

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Abstract

The first rhodium-catalyzed annulation of N-benzoylsulfonamide (1) with isocyanide (2) through CiH activation is described. The transformation is broadly compatible with N-benzoylsulfonamides as well as isocyanides with different electronic properties. From a practical point of view, this method provides the most straightforward approach to a series of 3-(imino) isoindolinones (3). Ts=4-toluenesulfonyl.

Original languageEnglish (US)
Pages (from-to)12591-12595
Number of pages5
JournalChemistry - A European Journal
Volume17
Issue number45
DOIs
Publication statusPublished - Nov 4 2011

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Keywords

  • annulations
  • CiH activation
  • heterocycles
  • isocyanide
  • rhodium

ASJC Scopus subject areas

  • Chemistry(all)

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