Rhodium-catalyzed NH insertion of pyridyl carbenes derived from pyridotriazoles: A general and efficient approach to 2-picolylamines and imidazo[1,5-a]pyridines

Yi Shi, Anton V. Gulevich, Vladimir Gevorgyan

Research output: Contribution to journalArticle

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Abstract

A general and efficient NH insertion reaction of rhodium pyridyl carbenes derived from pyridotriazoles was developed. Various NH-containing compounds, including amides, anilines, enamines, and aliphatic amines, smoothly underwent the NH insertion reaction to afford 2-picolylamine derivatives. The developed transformation was further utilized in a facile one-pot synthesis of imidazo[1,5-a]pyridines.

Original languageEnglish (US)
Pages (from-to)14191-14195
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number51
DOIs
StatePublished - Dec 15 2014

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Keywords

  • Annulations
  • Carbenes
  • Heterocycles
  • Rhodium
  • Synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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