Abstract
The efficacy of rifampin prophylaxis (20 mg/kg/day in two doses for four days) in eliminating pharyngeal Hemophilus influenzae type b from household contacts of 38 patients with invasive Hemophilus disease was evaluated in a prospective, placebo-controlled fashion. At the end of treatment, rifampin efficacy was 91% in subjects younger than 5 years of age and 100% in those subjects older than 5 years. The H influenzae type b carrier rate of rifampin-treated subjects was significantly smaller than that of placebo-treated subjects one month after prophylaxis. However, 22% to 25% of rifampin-treated carriers younger than 5 years of age were colonized with H influenzae type b, based on cultures obtained one to four weeks after prophylaxis, while approximately 75% of placebo-treated carriers were still positive at this time.
Original language | English (US) |
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Pages (from-to) | 627-632 |
Number of pages | 6 |
Journal | American Journal of Diseases of Children |
Volume | 137 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1983 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health