RIM1α and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia

Jacqueline Blundell, Pascal S. Kaeser, Thomas C. Südhof, Craig M. Powell

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Several presynaptic proteins involved in neurotransmitter release in the CNS have been implicated in schizophrenia in human clinical genetic studies, in postmortem studies, and in studies of putative animal models of schizophrenia. The presynaptic protein RIM1α mediates presynaptic plasticity and cognitive function. We now demonstrate that mice deficient in RIM1α exhibit abnormalities in multiple schizophrenia-relevant behavioral tasks including prepulse inhibition, response to psychotomimetic drugs, and social interaction. These schizophrenia-relevant behavioral findings are relatively selective to RIM1α-deficient mice, as mice bearing mutations in the RIM1α binding partners Rab3A or synaptotagmin 1 only show decreased prepulse inhibition. In addition to RIM1α's involvement in multiple behavioral abnormalities, these data suggest that alterations in presynaptic forms of short-term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating.

Original languageEnglish (US)
Pages (from-to)5326-5333
Number of pages8
JournalJournal of Neuroscience
Volume30
Issue number15
DOIs
StatePublished - Apr 14 2010

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'RIM1α and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia'. Together they form a unique fingerprint.

  • Cite this