RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

Ayaz Najafov, Hoang Son Luu, Adnan K. Mookhtiar, Lauren Mifflin, Hong guang Xia, Palak P. Amin, Alban Ordureau, Huibing Wang, Junying Yuan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

RIPK1 scaffold activity is known to have a pro-survival role in TNFα signaling. Najafov et al. discover an unexpected role for RIPK1 scaffold activity in mediating mTORC1 inhibition by AMPK during energetic stress. Mechanistic studies reveal that RIPK1 is involved in regulating TSC2 phosphorylation at Ser1387 by AMPK. Reduced phosphorylation of this site in RIPK1-deficient cells results in a chronically elevated mTORC1 activity and lysosomal dysfunction.

Original languageEnglish (US)
Pages (from-to)370-385.e7
JournalMolecular cell
Volume81
Issue number2
DOIs
StatePublished - Jan 21 2021
Externally publishedYes

Keywords

  • AMPK
  • CASP8
  • MLKL
  • RIPK1
  • RIPK3
  • TSC2
  • lysosome
  • mTORC1
  • neonatal lethality

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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