Abstract
Risankizumab, a fully human IgG monoclonal antibody inhibitor of IL-23, is a therapeutic agent currently in late stage development for use in the treatment of moderate-to-severe plaque psoriasis. It is a biologic agent similar to guselkumab and tildrakizumab which targets IL-23 specifically, and has been primarily developed for use in moderate-to-severe psoriasis. USA-based pharmaceutical company Abbvie submitted it for a Biologics License Application to the US Food and Drug Administration (FDA) in April 2018. Risankizumab is the result of a collaboration between the German company Boehringer Ingelheim and Abbvie, which together are leading the future development and commercialization of risankizumab globally. The results from Phase I to Phase III clinical trials of risankizumab show it is highly effective and its FDA-approval in 2018 is likely. In this article we provide an independent expert opinion on the efficacy and safety of risankizumab in psoriasis based on a full review of the literature.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3879-3883 |
| Number of pages | 5 |
| Journal | Drug Design, Development and Therapy |
| Volume | 12 |
| DOIs | |
| State | Published - 2018 |
| Externally published | Yes |
Keywords
- Efficacy
- Human monoclonal antibody
- Interleukin-23
- Psoriasis
- Risankizumab
- Safety
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
- Drug Discovery