Risk factors and clinical impact of central line infections in the surgical intensive care unit

Charalambos Charalambous, Sandra M. Swoboda, James Dick, Trish Perl, Pamela A. Lipsett

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the risk factors and clinical impact of central line infections in critically ill surgical patients. Design: Retrospective study. Setting: The surgical intensive care unit of a large tertiary care university hospital. Patients: A total of 232 consecutive central line catheters sent for culture from patients in a surgical intensive care unit during 1996 and 1997. Catheters were sent for microbiologic analysis when the patient was clinically infected and the central line was a possible source. Interventions: None. Main Outcome Measures: Risk factors associated and clinical impact of a positive catheter culture. Results: Of 232 consecutive catheters from 93 patients sent for microbiologic analysis, 114 catheters (49%) had no growth, 40 (17%) were colonized (<15 colonies), and 78 (34%) were considered infected (≥ 15 colonies). Univariate analysis showed that site (internal jugular vs subclavian, P<.001), catheter use (monitoring > dialysis > fluid > nutrition, P = .006), placement in the operating room vs the intensive care unit (P = .02), and placement of a new catheter (> guide wire, > new site, P = .003) were all significant factors. Surprisingly, neither the number of lumens nor the duration of the catheter in situ were predictors when a catheter was suspected and not proved infected compared with a suspected and proved catheter infection. In the multiple regression model, the placement of the catheter in the internal jugular position was the single most important predictor of a catheter infection (P<.001; odds ratio, 1.83 95% confidence interval [CI], 1.41-2.37). The presence or absence of a specific clinical sign of infection was not predictive of a proved catheter infection. Eighty-six percent of patients had gram-positive bacteria identified on the culture, while the remaining patients had gram-negative bacteria or Candida identified. Of the catheter infections, 68% were monomicrobial, whereas 32% were polymicrobial. Of the catheters sent for microbiologic analysis, 209 (90%) had concurrent peripheral blood cultures for analysis. Nineteen (32%) with no growth from the catheter, and 14 (23%) of colonized catheters had concurrent bacteremia; all had another identifiable cause of infection Twenty-seven (45%) of infected catheters had a concurrent bacteremia, and 9 of 27 had a second site positive for the same organism. Death related to the infection occurred in 15 patients, 2 in the first 72 hours and 13 in the following 14 days. Conclusions: Central line infections remain an important cause of morbidity and mortality. Comprehensive review of hospital practices may show a directed focus for performance improvement practices. At our institution, internal jugular catheters have the highest rate of infection. This may suggest breaks in technique during catheter insertion or during catheter maintenance and care.

Original languageEnglish (US)
Pages (from-to)1241-1246
Number of pages6
JournalArchives of Surgery
Volume133
Issue number11
StatePublished - Jan 1 1998

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Critical Care
Intensive Care Units
Catheters
Infection
Bacteremia
Neck
Gram-Positive Bacteria
Tertiary Healthcare
Operating Rooms

ASJC Scopus subject areas

  • Surgery

Cite this

Charalambous, C., Swoboda, S. M., Dick, J., Perl, T., & Lipsett, P. A. (1998). Risk factors and clinical impact of central line infections in the surgical intensive care unit. Archives of Surgery, 133(11), 1241-1246.

Risk factors and clinical impact of central line infections in the surgical intensive care unit. / Charalambous, Charalambos; Swoboda, Sandra M.; Dick, James; Perl, Trish; Lipsett, Pamela A.

In: Archives of Surgery, Vol. 133, No. 11, 01.01.1998, p. 1241-1246.

Research output: Contribution to journalArticle

Charalambous, C, Swoboda, SM, Dick, J, Perl, T & Lipsett, PA 1998, 'Risk factors and clinical impact of central line infections in the surgical intensive care unit', Archives of Surgery, vol. 133, no. 11, pp. 1241-1246.
Charalambous, Charalambos ; Swoboda, Sandra M. ; Dick, James ; Perl, Trish ; Lipsett, Pamela A. / Risk factors and clinical impact of central line infections in the surgical intensive care unit. In: Archives of Surgery. 1998 ; Vol. 133, No. 11. pp. 1241-1246.
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abstract = "Objective: To determine the risk factors and clinical impact of central line infections in critically ill surgical patients. Design: Retrospective study. Setting: The surgical intensive care unit of a large tertiary care university hospital. Patients: A total of 232 consecutive central line catheters sent for culture from patients in a surgical intensive care unit during 1996 and 1997. Catheters were sent for microbiologic analysis when the patient was clinically infected and the central line was a possible source. Interventions: None. Main Outcome Measures: Risk factors associated and clinical impact of a positive catheter culture. Results: Of 232 consecutive catheters from 93 patients sent for microbiologic analysis, 114 catheters (49{\%}) had no growth, 40 (17{\%}) were colonized (<15 colonies), and 78 (34{\%}) were considered infected (≥ 15 colonies). Univariate analysis showed that site (internal jugular vs subclavian, P<.001), catheter use (monitoring > dialysis > fluid > nutrition, P = .006), placement in the operating room vs the intensive care unit (P = .02), and placement of a new catheter (> guide wire, > new site, P = .003) were all significant factors. Surprisingly, neither the number of lumens nor the duration of the catheter in situ were predictors when a catheter was suspected and not proved infected compared with a suspected and proved catheter infection. In the multiple regression model, the placement of the catheter in the internal jugular position was the single most important predictor of a catheter infection (P<.001; odds ratio, 1.83 95{\%} confidence interval [CI], 1.41-2.37). The presence or absence of a specific clinical sign of infection was not predictive of a proved catheter infection. Eighty-six percent of patients had gram-positive bacteria identified on the culture, while the remaining patients had gram-negative bacteria or Candida identified. Of the catheter infections, 68{\%} were monomicrobial, whereas 32{\%} were polymicrobial. Of the catheters sent for microbiologic analysis, 209 (90{\%}) had concurrent peripheral blood cultures for analysis. Nineteen (32{\%}) with no growth from the catheter, and 14 (23{\%}) of colonized catheters had concurrent bacteremia; all had another identifiable cause of infection Twenty-seven (45{\%}) of infected catheters had a concurrent bacteremia, and 9 of 27 had a second site positive for the same organism. Death related to the infection occurred in 15 patients, 2 in the first 72 hours and 13 in the following 14 days. Conclusions: Central line infections remain an important cause of morbidity and mortality. Comprehensive review of hospital practices may show a directed focus for performance improvement practices. At our institution, internal jugular catheters have the highest rate of infection. This may suggest breaks in technique during catheter insertion or during catheter maintenance and care.",
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N2 - Objective: To determine the risk factors and clinical impact of central line infections in critically ill surgical patients. Design: Retrospective study. Setting: The surgical intensive care unit of a large tertiary care university hospital. Patients: A total of 232 consecutive central line catheters sent for culture from patients in a surgical intensive care unit during 1996 and 1997. Catheters were sent for microbiologic analysis when the patient was clinically infected and the central line was a possible source. Interventions: None. Main Outcome Measures: Risk factors associated and clinical impact of a positive catheter culture. Results: Of 232 consecutive catheters from 93 patients sent for microbiologic analysis, 114 catheters (49%) had no growth, 40 (17%) were colonized (<15 colonies), and 78 (34%) were considered infected (≥ 15 colonies). Univariate analysis showed that site (internal jugular vs subclavian, P<.001), catheter use (monitoring > dialysis > fluid > nutrition, P = .006), placement in the operating room vs the intensive care unit (P = .02), and placement of a new catheter (> guide wire, > new site, P = .003) were all significant factors. Surprisingly, neither the number of lumens nor the duration of the catheter in situ were predictors when a catheter was suspected and not proved infected compared with a suspected and proved catheter infection. In the multiple regression model, the placement of the catheter in the internal jugular position was the single most important predictor of a catheter infection (P<.001; odds ratio, 1.83 95% confidence interval [CI], 1.41-2.37). The presence or absence of a specific clinical sign of infection was not predictive of a proved catheter infection. Eighty-six percent of patients had gram-positive bacteria identified on the culture, while the remaining patients had gram-negative bacteria or Candida identified. Of the catheter infections, 68% were monomicrobial, whereas 32% were polymicrobial. Of the catheters sent for microbiologic analysis, 209 (90%) had concurrent peripheral blood cultures for analysis. Nineteen (32%) with no growth from the catheter, and 14 (23%) of colonized catheters had concurrent bacteremia; all had another identifiable cause of infection Twenty-seven (45%) of infected catheters had a concurrent bacteremia, and 9 of 27 had a second site positive for the same organism. Death related to the infection occurred in 15 patients, 2 in the first 72 hours and 13 in the following 14 days. Conclusions: Central line infections remain an important cause of morbidity and mortality. Comprehensive review of hospital practices may show a directed focus for performance improvement practices. At our institution, internal jugular catheters have the highest rate of infection. This may suggest breaks in technique during catheter insertion or during catheter maintenance and care.

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