Risk factors associated with pediatric acute recurrent and chronic pancreatitis: Lessons from INSPPIRE

Soma Kumar, Chee Y. Ooi, Steven Werlin, Maisam Abu-El-Haija, Bradley Barth, Melena D. Bellin, Peter R. Durie, Douglas S. Fishman, Steven D. Freedman, Cheryl Gariepy, Matthew J. Giefer, Tanja Gonska, Melvin B. Heyman, Ryan Himes, Sohail Z. Husain, Tom K. Lin, Mark E. Lowe, Veronique Morinville, Joseph J. Palermo, John F. PohlSarah Jane Schwarzenberg, David Troendle, Michael Wilschanski, M. Bridget Zimmerman, Aliye Uc

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

IMPORTANCE: Pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood. OBJECTIVE: To characterize and identify risk factors associated with ARP and CP in childhood. DESIGN, SETTING, AND PARTICIPANTS: A multinational cross-sectional study of children with ARP or CP at the time of enrollment to the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) study at participant institutions of the INSPPIRE Consortium. From August 22, 2012, to February 8, 2015,155 children with ARP and 146 with CP (aged 2 test or Fisher exact test for categorical variables. Disease burden variables (pain variables, hospital/emergency department visits, missed school days) were compared using Wilcoxon rank sum test. MAIN OUTCOMES AND MEASURES: Demographic characteristics, risk factors, abdominal pain, and disease burden. RESULTS: A total of 301 children were enrolled (mean [SD] age, 11.9 [4.5] years; 172 [57%] female); 155 had ARP and 146 had CP. The majority of children with CP (123 of 146 [84%]) reported prior recurrent episodes of acute pancreatitis. Sex distribution was similar between the groups (57% female in both). Hispanic children were less likely to have CP than ARP (17% vs 28%, respectively; odds ratio [OR] = 0.51; 95% CI, 0.29-0.92; P =.02). At least 1 gene mutation in pancreatitis-related genes was found in 48% of patients with ARP vs 73% of patients with CP(P

Original languageEnglish (US)
Pages (from-to)562-569
Number of pages8
JournalJAMA Pediatrics
Volume170
Issue number6
DOIs
StatePublished - Jun 1 2016

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Chronic Pancreatitis
Pancreatitis
Pediatrics
Nonparametric Statistics
Sex Distribution
Hospital Departments
Hispanic Americans
Abdominal Pain
Genes
Hospital Emergency Service
Cross-Sectional Studies
Odds Ratio
Demography
Pain
Mutation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Risk factors associated with pediatric acute recurrent and chronic pancreatitis : Lessons from INSPPIRE. / Kumar, Soma; Ooi, Chee Y.; Werlin, Steven; Abu-El-Haija, Maisam; Barth, Bradley; Bellin, Melena D.; Durie, Peter R.; Fishman, Douglas S.; Freedman, Steven D.; Gariepy, Cheryl; Giefer, Matthew J.; Gonska, Tanja; Heyman, Melvin B.; Himes, Ryan; Husain, Sohail Z.; Lin, Tom K.; Lowe, Mark E.; Morinville, Veronique; Palermo, Joseph J.; Pohl, John F.; Schwarzenberg, Sarah Jane; Troendle, David; Wilschanski, Michael; Zimmerman, M. Bridget; Uc, Aliye.

In: JAMA Pediatrics, Vol. 170, No. 6, 01.06.2016, p. 562-569.

Research output: Contribution to journalArticle

Kumar, S, Ooi, CY, Werlin, S, Abu-El-Haija, M, Barth, B, Bellin, MD, Durie, PR, Fishman, DS, Freedman, SD, Gariepy, C, Giefer, MJ, Gonska, T, Heyman, MB, Himes, R, Husain, SZ, Lin, TK, Lowe, ME, Morinville, V, Palermo, JJ, Pohl, JF, Schwarzenberg, SJ, Troendle, D, Wilschanski, M, Zimmerman, MB & Uc, A 2016, 'Risk factors associated with pediatric acute recurrent and chronic pancreatitis: Lessons from INSPPIRE', JAMA Pediatrics, vol. 170, no. 6, pp. 562-569. https://doi.org/10.1001/jamapediatrics.2015.4955
Kumar, Soma ; Ooi, Chee Y. ; Werlin, Steven ; Abu-El-Haija, Maisam ; Barth, Bradley ; Bellin, Melena D. ; Durie, Peter R. ; Fishman, Douglas S. ; Freedman, Steven D. ; Gariepy, Cheryl ; Giefer, Matthew J. ; Gonska, Tanja ; Heyman, Melvin B. ; Himes, Ryan ; Husain, Sohail Z. ; Lin, Tom K. ; Lowe, Mark E. ; Morinville, Veronique ; Palermo, Joseph J. ; Pohl, John F. ; Schwarzenberg, Sarah Jane ; Troendle, David ; Wilschanski, Michael ; Zimmerman, M. Bridget ; Uc, Aliye. / Risk factors associated with pediatric acute recurrent and chronic pancreatitis : Lessons from INSPPIRE. In: JAMA Pediatrics. 2016 ; Vol. 170, No. 6. pp. 562-569.
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AU - Kumar, Soma

AU - Ooi, Chee Y.

AU - Werlin, Steven

AU - Abu-El-Haija, Maisam

AU - Barth, Bradley

AU - Bellin, Melena D.

AU - Durie, Peter R.

AU - Fishman, Douglas S.

AU - Freedman, Steven D.

AU - Gariepy, Cheryl

AU - Giefer, Matthew J.

AU - Gonska, Tanja

AU - Heyman, Melvin B.

AU - Himes, Ryan

AU - Husain, Sohail Z.

AU - Lin, Tom K.

AU - Lowe, Mark E.

AU - Morinville, Veronique

AU - Palermo, Joseph J.

AU - Pohl, John F.

AU - Schwarzenberg, Sarah Jane

AU - Troendle, David

AU - Wilschanski, Michael

AU - Zimmerman, M. Bridget

AU - Uc, Aliye

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N2 - IMPORTANCE: Pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are poorly understood. OBJECTIVE: To characterize and identify risk factors associated with ARP and CP in childhood. DESIGN, SETTING, AND PARTICIPANTS: A multinational cross-sectional study of children with ARP or CP at the time of enrollment to the INSPPIRE (International Study Group of Pediatric Pancreatitis: In Search for a Cure) study at participant institutions of the INSPPIRE Consortium. From August 22, 2012, to February 8, 2015,155 children with ARP and 146 with CP (aged 2 test or Fisher exact test for categorical variables. Disease burden variables (pain variables, hospital/emergency department visits, missed school days) were compared using Wilcoxon rank sum test. MAIN OUTCOMES AND MEASURES: Demographic characteristics, risk factors, abdominal pain, and disease burden. RESULTS: A total of 301 children were enrolled (mean [SD] age, 11.9 [4.5] years; 172 [57%] female); 155 had ARP and 146 had CP. The majority of children with CP (123 of 146 [84%]) reported prior recurrent episodes of acute pancreatitis. Sex distribution was similar between the groups (57% female in both). Hispanic children were less likely to have CP than ARP (17% vs 28%, respectively; odds ratio [OR] = 0.51; 95% CI, 0.29-0.92; P =.02). At least 1 gene mutation in pancreatitis-related genes was found in 48% of patients with ARP vs 73% of patients with CP(P

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