Risk factors for earlier dementia onset in autopsy-confirmed Alzheimer's disease, mixed Alzheimer's with Lewy bodies, and pure Lewy body disease

Jeff Schaffert, Christian LoBue, Charles L. White, Kristin Wilmoth, Nyaz Didehbani, Laura Lacritz, Trung Nguyen, Matthew E. Peters, Lindy Fields, Chengxi Li, C. Munro Cullum

Research output: Contribution to journalArticle

Abstract

Introduction: Clinical Alzheimer's disease (AD) and dementia with Lewy bodies often have mixed AD and Lewy pathology, making it difficult to delineate risk factors. Methods: Six risk factors for earlier dementia onset due to autopsy-confirmed AD (n = 647), mixed AD and Lewy body disease (AD + LBD; n = 221), and LBD (n = 63) were entered into multiple linear regressions using data from the National Alzheimer's Coordinating Center. Results: In AD and AD + LBD, male sex and apolipoprotein E (APOE) ɛ4 alleles each predicted a 2- to 3-year-earlier onset and depression predicted a 3-year-earlier onset. In LBD, higher education predicted earlier onset and depression predicted a 5.5-year-earlier onset. Discussion: Male sex and APOE ɛ4 alleles increase risk for earlier dementia onset in AD but not LBD. Depression increases risk for earlier dementia onset in AD, LBD, and AD + LBD, but evaluating the course, treatment, and severity is needed in future studies.

Original languageEnglish (US)
Pages (from-to)524-530
Number of pages7
JournalAlzheimer's and Dementia
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • Alzheimer's disease
  • dementia
  • Lewy body disease
  • onset
  • risk factors

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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