Risk factors for readmission after initial diagnosis in children with acute lymphoblastic leukemia

Tamra L. Slone, Rachna Rai, Naveed Ahmad, Naomi J. Winick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. Specific hospital discharge criteria following the initial diagnosis of children with acute lymphoblastic leukemia (ALL) have not been reported. This retrospective cohort study was designed to identify risk factors for readmission during induction therapy, to assist with development of discharge guidelines. Procedure. We reviewed the records of 142 consecutive children with newly diagnosed B-precursor ALL and found 129 eligible patients. Chi square, t-test, and multivariate logistic regression analysis were used to compare differences in absolute neutrophil count (ANC), NCI risk status, age, type of corticosteroid administered, and other potential risk factors for readmission during induction therapy. Results. ANC at initial hospital discharge was the only significant predictor of readmission for fever during induction therapy (P = 0.006) by multivariate analysis. Specifically an ANC ≤200/mm3 at discharge had the strongest association with readmission for fever (OR 3.3, 95% CI 1.422, 7.729). Conclusion. An ANC >200/mm3, in a clinically stable patient, is associated with minimal risk of readmission during induction therapy following the initial diagnosis of ALL.

Original languageEnglish (US)
Pages (from-to)375-379
Number of pages5
JournalPediatric Blood and Cancer
Volume51
Issue number3
DOIs
StatePublished - Sep 2008

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neutrophils
Fever
Chi-Square Distribution
Therapeutics
Adrenal Cortex Hormones
Cohort Studies
Multivariate Analysis
Retrospective Studies
Logistic Models
Regression Analysis
Guidelines

Keywords

  • Acute lymphoblastic leukemia
  • Children
  • Fever
  • Induction
  • Infection
  • Neutropenia

ASJC Scopus subject areas

  • Cancer Research
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Risk factors for readmission after initial diagnosis in children with acute lymphoblastic leukemia. / Slone, Tamra L.; Rai, Rachna; Ahmad, Naveed; Winick, Naomi J.

In: Pediatric Blood and Cancer, Vol. 51, No. 3, 09.2008, p. 375-379.

Research output: Contribution to journalArticle

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