Risk of chromosomal abnormalities, with emphasis on live-born offspring of young mothers

B. B. Little, S. M. Ramin, B. S. Cambridge, N. R. Schneider, D. S. Cohen, L. M. Snell, M. J. Harrod, W. L. Johnston

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Abstract

In a large public urban hospital obstetrics service with > 123,000 deliveries in a 10-year period (1980-89), the frequencies (0.12%) of any type of chromosomal abnormality and of trisomy syndromes were analyzed for maternal age-related risk, by logistic regression. Focusing on very young gravidas, we found that in the study period there were 9,332 births (7.5% of all deliveries) to mothers ≤ 16 years old. Estimated risks of chromosomal abnormalities among offspring associated with very young maternal age (9-16 years) were similar to those age-associated risks of mothers 20-29 years old. Risks of chromosomal abnormalities increase with advancing maternal age and are independent of ethnicity.

Original languageEnglish (US)
Pages (from-to)1178-1185
Number of pages8
JournalAmerican Journal of Human Genetics
Volume57
Issue number5
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Little, B. B., Ramin, S. M., Cambridge, B. S., Schneider, N. R., Cohen, D. S., Snell, L. M., Harrod, M. J., & Johnston, W. L. (1995). Risk of chromosomal abnormalities, with emphasis on live-born offspring of young mothers. American Journal of Human Genetics, 57(5), 1178-1185.