Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma

Jeff S. Ehresman, Tomas Garzon-Muvdi, Davis Rogers, Michael Lim, Gary L. Gallia, Jon Weingart, Henry Brem, Chetan Bettegowda, Kaisorn L. Chaichana

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Object Meningiomas occur in various intracranial locations. Each location is associated with a unique set of surgical nuances and risk profiles. The incidence and risk factors that predispose patients to certain deficits based on tumor locations are unclear. This study aimed to determine which preoperative factors increase the risk of patients having new deficits after surgery based on tumor location for patients undergoing intracranial meningioma surgery. Methods Adult patients who underwent primary, nonbiopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate logistic regression analyses were used to identify associations with postoperative deficits based on tumor location. Results Postoperatively, from the 761 included patients, there were 39 motor deficits (5.1%), 23 vision deficits (3.0%), 19 language deficits (2.5%), 27 seizures (3.5%), and 26 cognitive deficits (3.4%). The factors independently associated with any postoperative deficits were preoperative radiation (hazard ratio [HR] [95% confidence interval, CI] 3.000 [1.346-6.338], p = 0.008), cerebellopontine angle tumors (HR [95% CI] 2.126 [1.094-3.947], p = 0.03), Simpson grade 4 resections (HR [95% CI] 2.000 [1.271-3.127], p = 0.003), preoperative motor deficits (HR [95% CI] 1.738 [1.005-2.923], p = 0.048), preoperative cognitive deficits (HR [95% CI] 2.033 [1.144-3.504], p = 0.02), and perioperative pulmonary embolisms (HR [95% CI] 11.741 [2.803-59.314], p = 0.0009). Conclusion Consideration of the factors associated with postoperative deficits in this study may help guide treatment strategies for patients with meningiomas.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalJournal of Neurological Surgery, Part B: Skull Base
Volume80
Issue number1
DOIs
StatePublished - Jul 17 2018
Externally publishedYes

Fingerprint

Meningioma
Confidence Intervals
Neoplasms
Acoustic Neuroma
Tertiary Healthcare
Pulmonary Embolism
Seizures
Language
Logistic Models
Regression Analysis
Radiation
Incidence

Keywords

  • complications
  • meningioma
  • postoperative deficits
  • risk factors
  • surgical resection
  • tumor location

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma. / Ehresman, Jeff S.; Garzon-Muvdi, Tomas; Rogers, Davis; Lim, Michael; Gallia, Gary L.; Weingart, Jon; Brem, Henry; Bettegowda, Chetan; Chaichana, Kaisorn L.

In: Journal of Neurological Surgery, Part B: Skull Base, Vol. 80, No. 1, 17.07.2018, p. 59-66.

Research output: Contribution to journalArticle

Ehresman, Jeff S. ; Garzon-Muvdi, Tomas ; Rogers, Davis ; Lim, Michael ; Gallia, Gary L. ; Weingart, Jon ; Brem, Henry ; Bettegowda, Chetan ; Chaichana, Kaisorn L. / Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma. In: Journal of Neurological Surgery, Part B: Skull Base. 2018 ; Vol. 80, No. 1. pp. 59-66.
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abstract = "Object Meningiomas occur in various intracranial locations. Each location is associated with a unique set of surgical nuances and risk profiles. The incidence and risk factors that predispose patients to certain deficits based on tumor locations are unclear. This study aimed to determine which preoperative factors increase the risk of patients having new deficits after surgery based on tumor location for patients undergoing intracranial meningioma surgery. Methods Adult patients who underwent primary, nonbiopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate logistic regression analyses were used to identify associations with postoperative deficits based on tumor location. Results Postoperatively, from the 761 included patients, there were 39 motor deficits (5.1{\%}), 23 vision deficits (3.0{\%}), 19 language deficits (2.5{\%}), 27 seizures (3.5{\%}), and 26 cognitive deficits (3.4{\%}). The factors independently associated with any postoperative deficits were preoperative radiation (hazard ratio [HR] [95{\%} confidence interval, CI] 3.000 [1.346-6.338], p = 0.008), cerebellopontine angle tumors (HR [95{\%} CI] 2.126 [1.094-3.947], p = 0.03), Simpson grade 4 resections (HR [95{\%} CI] 2.000 [1.271-3.127], p = 0.003), preoperative motor deficits (HR [95{\%} CI] 1.738 [1.005-2.923], p = 0.048), preoperative cognitive deficits (HR [95{\%} CI] 2.033 [1.144-3.504], p = 0.02), and perioperative pulmonary embolisms (HR [95{\%} CI] 11.741 [2.803-59.314], p = 0.0009). Conclusion Consideration of the factors associated with postoperative deficits in this study may help guide treatment strategies for patients with meningiomas.",
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T1 - Risk of Developing Postoperative Deficits Based on Tumor Location after Surgical Resection of an Intracranial Meningioma

AU - Ehresman, Jeff S.

AU - Garzon-Muvdi, Tomas

AU - Rogers, Davis

AU - Lim, Michael

AU - Gallia, Gary L.

AU - Weingart, Jon

AU - Brem, Henry

AU - Bettegowda, Chetan

AU - Chaichana, Kaisorn L.

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N2 - Object Meningiomas occur in various intracranial locations. Each location is associated with a unique set of surgical nuances and risk profiles. The incidence and risk factors that predispose patients to certain deficits based on tumor locations are unclear. This study aimed to determine which preoperative factors increase the risk of patients having new deficits after surgery based on tumor location for patients undergoing intracranial meningioma surgery. Methods Adult patients who underwent primary, nonbiopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate logistic regression analyses were used to identify associations with postoperative deficits based on tumor location. Results Postoperatively, from the 761 included patients, there were 39 motor deficits (5.1%), 23 vision deficits (3.0%), 19 language deficits (2.5%), 27 seizures (3.5%), and 26 cognitive deficits (3.4%). The factors independently associated with any postoperative deficits were preoperative radiation (hazard ratio [HR] [95% confidence interval, CI] 3.000 [1.346-6.338], p = 0.008), cerebellopontine angle tumors (HR [95% CI] 2.126 [1.094-3.947], p = 0.03), Simpson grade 4 resections (HR [95% CI] 2.000 [1.271-3.127], p = 0.003), preoperative motor deficits (HR [95% CI] 1.738 [1.005-2.923], p = 0.048), preoperative cognitive deficits (HR [95% CI] 2.033 [1.144-3.504], p = 0.02), and perioperative pulmonary embolisms (HR [95% CI] 11.741 [2.803-59.314], p = 0.0009). Conclusion Consideration of the factors associated with postoperative deficits in this study may help guide treatment strategies for patients with meningiomas.

AB - Object Meningiomas occur in various intracranial locations. Each location is associated with a unique set of surgical nuances and risk profiles. The incidence and risk factors that predispose patients to certain deficits based on tumor locations are unclear. This study aimed to determine which preoperative factors increase the risk of patients having new deficits after surgery based on tumor location for patients undergoing intracranial meningioma surgery. Methods Adult patients who underwent primary, nonbiopsy resection of a meningioma at a tertiary care institution between 2007 and 2015 were retrospectively reviewed. Stepwise multivariate logistic regression analyses were used to identify associations with postoperative deficits based on tumor location. Results Postoperatively, from the 761 included patients, there were 39 motor deficits (5.1%), 23 vision deficits (3.0%), 19 language deficits (2.5%), 27 seizures (3.5%), and 26 cognitive deficits (3.4%). The factors independently associated with any postoperative deficits were preoperative radiation (hazard ratio [HR] [95% confidence interval, CI] 3.000 [1.346-6.338], p = 0.008), cerebellopontine angle tumors (HR [95% CI] 2.126 [1.094-3.947], p = 0.03), Simpson grade 4 resections (HR [95% CI] 2.000 [1.271-3.127], p = 0.003), preoperative motor deficits (HR [95% CI] 1.738 [1.005-2.923], p = 0.048), preoperative cognitive deficits (HR [95% CI] 2.033 [1.144-3.504], p = 0.02), and perioperative pulmonary embolisms (HR [95% CI] 11.741 [2.803-59.314], p = 0.0009). Conclusion Consideration of the factors associated with postoperative deficits in this study may help guide treatment strategies for patients with meningiomas.

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