TY - JOUR
T1 - Risk of development of treated retinopathy of prematurity in very low birth weight infants
AU - Gonski, Samantha
AU - Hupp, Susan R.
AU - Cotten, C. Michael
AU - Clark, Reese H.
AU - Laughon, Matthew
AU - Watt, Kevin
AU - Hornik, Christoph P.
AU - Kumar, Karan
AU - Smith, P. Brian
AU - Greenberg, Rachel G.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: Quantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines. Study design: Among infants ≤1500 g birth weight or ≤30 weeks gestation screened for ROP from 2006–2015, we developed a risk prediction model to identify infants treated for ROP. We applied our model to a separate infant cohort discharged in 2016. Result: Seventy-five thousand eight hundred and twenty one infants met inclusion criteria; 2306 (3%) were treated for ROP. Infants with several risk factor combinations (no ventilator support or oxygen on postnatal day 28, no history of necrotizing enterocolitis, and no intraventricular hemorrhage) were at low risk of ROP. Applied to 6127 infants discharged in 2016, our model had 97.9% sensitivity, 63.3% specificity, positive predictive value of 4.0%, and negative predictive value of 99.9%. Conclusion: Large numbers of infants at low risk of developing ROP are required to undergo screening. Refining current ROP guidelines may reduce unnecessary examinations.
AB - Objective: Quantify the risk of treatment for retinopathy of prematurity (ROP) among infants meeting current U.S. screening guidelines. Study design: Among infants ≤1500 g birth weight or ≤30 weeks gestation screened for ROP from 2006–2015, we developed a risk prediction model to identify infants treated for ROP. We applied our model to a separate infant cohort discharged in 2016. Result: Seventy-five thousand eight hundred and twenty one infants met inclusion criteria; 2306 (3%) were treated for ROP. Infants with several risk factor combinations (no ventilator support or oxygen on postnatal day 28, no history of necrotizing enterocolitis, and no intraventricular hemorrhage) were at low risk of ROP. Applied to 6127 infants discharged in 2016, our model had 97.9% sensitivity, 63.3% specificity, positive predictive value of 4.0%, and negative predictive value of 99.9%. Conclusion: Large numbers of infants at low risk of developing ROP are required to undergo screening. Refining current ROP guidelines may reduce unnecessary examinations.
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U2 - 10.1038/s41372-019-0487-6
DO - 10.1038/s41372-019-0487-6
M3 - Article
C2 - 31492920
AN - SCOPUS:85073930513
SN - 0743-8346
VL - 39
SP - 1562
EP - 1568
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -