TY - JOUR
T1 - Risk of incident dementia in drug-untreated arterial hypertension
T2 - A population-based study
AU - Bermejo-Pareja, Félix
AU - Benito-León, Julián
AU - Louis, Elan D.
AU - Trincado, Rocío
AU - Carro, Eva
AU - Villarejo, Alberto
AU - De La Cámara, Agustín Gómez
N1 - Funding Information:
Partially funded by SAF2014-54371 ( FEDER funds), SEPAR 2015 and 2016, FUCAP 2014, and Menarini 2015.
Funding Information:
Partially funded by SAF2014-54371 (FEDER funds), SEPAR 2015 and 2016, FUCAP 2014, and Menarini 2015.
PY - 2010
Y1 - 2010
N2 - Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer's disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In a population-based study of older people in central Spain (NEDICES), non-demented participants were followed prospectively. Dementia at follow-up was diagnosed using DSM-IV criteria. Using Cox proportional hazards models, the risk of dementia was estimated in participants with drug-untreated hypertension and in participants with drug-treated hypertension versus controls. The 3,824 participants had a mean duration of follow-up of 3.2 years. Sixty-two (3.3%) of 1,870 participants without baseline hypertension developed incident dementia versus 78 (4.7%) of 1,657 with drug-treated, baseline hypertension and 19 (12.0%) with drug-untreated, baseline hypertension. In an unadjusted Cox model, risk of dementia was increased in participants with drug-untreated hypertension (relative risk [RR] =1.93, 95% confidence interval [CI]=1.15-3.23, p = 0.01) and in participants with drug-treated hypertension (RR =1.43, 95% CI= 1.02-2.0, p =0.035) versus participants without hypertension (reference group). In a fully adjusted Cox model, the risk of dementia remained increased in participants with drug-untreated hypertension (RR =2.38, 95% CI =1.32-4.29, p=0.004). Results were similar for risk of AD. Our results suggest that drug-untreated hypertension may be an independent risk factor for dementia and AD in the elderly.
AB - Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer's disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In a population-based study of older people in central Spain (NEDICES), non-demented participants were followed prospectively. Dementia at follow-up was diagnosed using DSM-IV criteria. Using Cox proportional hazards models, the risk of dementia was estimated in participants with drug-untreated hypertension and in participants with drug-treated hypertension versus controls. The 3,824 participants had a mean duration of follow-up of 3.2 years. Sixty-two (3.3%) of 1,870 participants without baseline hypertension developed incident dementia versus 78 (4.7%) of 1,657 with drug-treated, baseline hypertension and 19 (12.0%) with drug-untreated, baseline hypertension. In an unadjusted Cox model, risk of dementia was increased in participants with drug-untreated hypertension (relative risk [RR] =1.93, 95% confidence interval [CI]=1.15-3.23, p = 0.01) and in participants with drug-treated hypertension (RR =1.43, 95% CI= 1.02-2.0, p =0.035) versus participants without hypertension (reference group). In a fully adjusted Cox model, the risk of dementia remained increased in participants with drug-untreated hypertension (RR =2.38, 95% CI =1.32-4.29, p=0.004). Results were similar for risk of AD. Our results suggest that drug-untreated hypertension may be an independent risk factor for dementia and AD in the elderly.
KW - Dementia
KW - elderly
KW - epidemiology
KW - hypertension
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U2 - 10.3233/JAD-2010-101110
DO - 10.3233/JAD-2010-101110
M3 - Article
C2 - 20858957
AN - SCOPUS:78650668065
SN - 1387-2877
VL - 22
SP - 949
EP - 958
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -