Risk of Methylphenidate-Induced Prehypertension in Normotensive Adult Smokers With Attention Deficit Hyperactivity Disorder

Arthur N. Westover, Paul A. Nakonezny, Theresa Winhusen, Bryon Adinoff, Wanpen Vongpatanasin

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The authors studied predictors of methylphenidate-induced increases in blood pressure (BP). In this secondary analysis of a randomized, double-blind, placebo-controlled smoking cessation trial, nonhypertensive adult smokers with attention deficit hyperactivity disorder randomized to osmotic-release oral system methylphenidate (OROS-MPH) (n=115) were matched one-to-one on baseline systolic BP (SBP) (±5mmHg) with participants randomized to placebo (n=115) and followed for 10weeks. In adjusted mixed linear models of SBP and diastolic BP (DBP), baseline normal SBP (P<.0001) and DBP (P<.0001) were associated with significant OROS-MPH-induced increases compared with placebo, whereas significant increases were not observed in participants with baseline prehypertensive SBP (P=27) and DBP (P=79). Participants randomized to OROS-MPH with baseline normal BP had increased odds of developing either systolic (odds ratio [OR], 3.32; 95% confidence interval [CI], 1.41-8.37; P=006) or diastolic prehypertension (OR, 4.32; 95% CI, 1.56-14.0; P=004) compared with placebo using simple logistic regression. The authors demonstrated an augmented OROS-MPH-induced BP elevation and risk of prehypertension in adults with baseline normal BP. Significantly increased BP was not observed in adults with baseline prehypertension.

Original languageEnglish (US)
Pages (from-to)124-132
Number of pages9
JournalJournal of Clinical Hypertension
Volume15
Issue number2
DOIs
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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