Risperidone Treatment for Irritability in Fragile X Syndrome

Kelli C. Dominick, Logan K. Wink, Ernest V. Pedapati, Rebecca Shaffer, John A. Sweeney, Craig A. Erickson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: The goal of this study was to assess the effectiveness of risperidone monoantipsychotic therapy targeting irritability in patients with Fragile X syndrome (FXS) in a naturalistic outpatient clinical setting. Methods: We examined the use of risperidone, predominantly in combination with other nonantipsychotic psychotropic agents, targeting irritability in 21 male patients with FXS with a retrospective analysis of a prospectively collected large developmental disabilities-specific treatment database. Mean age at start of treatment, treatment duration, final dose, body mass index (BMI), and Clinical Global Impressions-Improvement (CGI-I) Scale score at final visit were determined, and changes with treatment were analyzed using paired t-tests. Results: Mean age at start of treatment was 14.0 years. The final mean dose of risperidone was 2.5 mg/day. The mean duration of treatment was 22 months. Seven (33.33%) participants were considered treatment responders based on the CGI-I. Change in BMI between initiation and cessation of treatment episode was not significant, however, these data were only available for a subset (n = 11) of patients. Conclusions: Risperidone may be effective in the treatment of irritability in males with FXS. The overall effectiveness of monoantipsychotic treatment with risperidone was limited in this study compared with previous published reports; however, this may be the result of differences in outcome measures as well as a reflection of the level of functioning and severity of irritability in this sample.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalJournal of Child and Adolescent Psychopharmacology
Volume28
Issue number4
DOIs
StatePublished - May 2018

Keywords

  • antipsychotics
  • fragile X syndrome
  • irritability
  • neurodevelopmental disorders
  • risperidone

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health
  • Pharmacology (medical)

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