TY - JOUR
T1 - RNA-binding proteins and mRNA turnover in trypanosomes
AU - D'Orso, Iván
AU - De Gaudenzi, Javier G.
AU - Frasch, Alberto C C
N1 - Funding Information:
This article cites only a small number of references. We apologize to people whose work was not referenced. We are indebted to Graciela Gotz and Juan José Cazzulo for critical reading of this article. Work in our laboratory was supported by grants from the World Bank/UNDP/WHO Special Program for Research and Training in Tropical Diseases (TDR), and the Agencia Nacional de Promoción Cientı́fica y Tecnológica, Argentina. The research from A.C.C.F. was supported, in part, by an International Research Scholars Grant from the Howard Hughes Medical Institute and a fellowship from the John Simon Guggenheim Memorial Foundation. I.D. is a research fellow from the National Research Council (CONICET), J.G.D. is a research fellow from the Comisión de Investigaciones Cientı́ficas (C.I.C.) and A.C.C.F. is a researcher from the CONICET, Argentina.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Trypanosomes, protozoan parasites of the order Kinetoplastida, control gene expression essentially through post-transcriptional mechanisms. Several motifs located mainly in the 3′ untranslated region, such as AU-rich elements (AREs), were recently shown to modulate mRNA half-life, and are able to modify mRNA abundance in vivo through the interaction with specific RNA-binding proteins. Along with the detection of an active exosome, decapping activities and a regulated 3′ to 5′ exonuclease activity stimulated by AREs, these results suggest that modulation of mRNA stability is essential in trypanosomes. These regulatory processes are specific for different developmental stages and thus relevant for allowing trypanosomes to adapt to variable environmental conditions.
AB - Trypanosomes, protozoan parasites of the order Kinetoplastida, control gene expression essentially through post-transcriptional mechanisms. Several motifs located mainly in the 3′ untranslated region, such as AU-rich elements (AREs), were recently shown to modulate mRNA half-life, and are able to modify mRNA abundance in vivo through the interaction with specific RNA-binding proteins. Along with the detection of an active exosome, decapping activities and a regulated 3′ to 5′ exonuclease activity stimulated by AREs, these results suggest that modulation of mRNA stability is essential in trypanosomes. These regulatory processes are specific for different developmental stages and thus relevant for allowing trypanosomes to adapt to variable environmental conditions.
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U2 - 10.1016/S1471-4922(03)00035-7
DO - 10.1016/S1471-4922(03)00035-7
M3 - Review article
C2 - 12689640
AN - SCOPUS:0037384759
SN - 1471-4922
VL - 19
SP - 151
EP - 155
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 4
ER -