RNA-binding proteins and mRNA turnover in trypanosomes

Iván D'Orso, Javier G. De Gaudenzi, Alberto C C Frasch

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Abstract

Trypanosomes, protozoan parasites of the order Kinetoplastida, control gene expression essentially through post-transcriptional mechanisms. Several motifs located mainly in the 3′ untranslated region, such as AU-rich elements (AREs), were recently shown to modulate mRNA half-life, and are able to modify mRNA abundance in vivo through the interaction with specific RNA-binding proteins. Along with the detection of an active exosome, decapping activities and a regulated 3′ to 5′ exonuclease activity stimulated by AREs, these results suggest that modulation of mRNA stability is essential in trypanosomes. These regulatory processes are specific for different developmental stages and thus relevant for allowing trypanosomes to adapt to variable environmental conditions.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalTrends in Parasitology
Volume19
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

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ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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