RNA interference in fungi: Pathways, functions, and applications

Yunkun Dang, Qiuying Yang, Zhihong Xue, Yi Liu

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, and gene regulation. Studies of Schizosaccharomyces pombe and Neurospora, and other fungi have uncovered surprisingly diverse small RNA biogenesis pathways, suggesting that fungi utilize RNAi-related pathways in various cellular processes to adapt to different environmental conditions. These studies also provided important insights into how RNAi functions in eukaryotic systems in general. In this review, we will discuss our current understanding of the fungal RNAi-related pathways and their functions, with a focus on filamentous fungi. We will also discuss how RNAi can be used as a tool in fungal research.

Original languageEnglish (US)
Pages (from-to)1148-1155
Number of pages8
JournalEukaryotic Cell
Volume10
Issue number9
DOIs
StatePublished - Sep 2011

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RNA Interference
Fungi
Fungal RNA
RNA
Neurospora
RNA Replicase
Heterochromatin
Schizosaccharomyces
Genes
Nucleotides
Research

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

RNA interference in fungi : Pathways, functions, and applications. / Dang, Yunkun; Yang, Qiuying; Xue, Zhihong; Liu, Yi.

In: Eukaryotic Cell, Vol. 10, No. 9, 09.2011, p. 1148-1155.

Research output: Contribution to journalArticle

Dang, Yunkun ; Yang, Qiuying ; Xue, Zhihong ; Liu, Yi. / RNA interference in fungi : Pathways, functions, and applications. In: Eukaryotic Cell. 2011 ; Vol. 10, No. 9. pp. 1148-1155.
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