RNA-mediated gene activation: Identifying a candidate RNA for preclinical development

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The ability to activate gene expression would provide new opportunities for drug development for diseases caused by inadequate or nonexistent expression of a therapeutic protein. Duplex RNAs that target gene promoters are one strategy for enhancing the expression of target genes. This chapter summarizes our understanding of mechanism behind gene activation by small RNAs that bind noncoding transcripts at gene promoters. We describe a path for choosing candidate genes for therapeutic development.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages161-171
Number of pages11
Volume983
DOIs
Publication statusPublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume983
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

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Keywords

  • Duplex RNA
  • Gene activation
  • Noncoding RNA
  • Nucleic acid therapeutics
  • RNA

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Corey, D. R. (2017). RNA-mediated gene activation: Identifying a candidate RNA for preclinical development. In Advances in Experimental Medicine and Biology (Vol. 983, pp. 161-171). (Advances in Experimental Medicine and Biology; Vol. 983). Springer New York LLC. https://doi.org/10.1007/978-981-10-4310-9_11