Robust fluoroscopic respiratory gating for lung cancer radiotherapy without implanted fiducial markers

Ying Cui, Jennifer G. Dy, Greg C. Sharp, Brian Alexander, Steve B. Jiang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

For gated lung cancer radiotherapy, it is difficult to generate accurate gating signals due to the large uncertainties when using external surrogates and the risk of pneumothorax when using implanted fiducial markers. We have previously investigated and demonstrated the feasibility of generating gating signals using the correlation scores between the reference template image and the fluoroscopic images acquired during the treatment. In this paper, we present an in-depth study, aiming at the improvement of robustness of the algorithm and its validation using multiple sets of patient data. Three different template generating and matching methods have been developed and evaluated: (1) single template method, (2) multiple template method, and (3) template clustering method. Using the fluoroscopic data acquired during patient setup before each fraction of treatment, reference templates are built that represent the tumour position and shape in the gating window, which is assumed to be at the end-of-exhale phase. For the single template method, all the setup images within the gating window are averaged to generate a composite template. For the multiple template method, each setup image in the gating window is considered as a reference template and used to generate an ensemble of correlation scores. All the scores are then combined to generate the gating signal. For the template clustering method, clustering (grouping of similar objects together) is performed to reduce the large number of reference templates into a few representative ones. Each of these methods has been evaluated against the reference gating signal as manually determined by a radiation oncologist. Five patient datasets were used for evaluation. In each case, gated treatments were simulated at both 35% and 50% duty cycles. False positive, negative and total error rates were computed. Experiments show that the single template method is sensitive to noise; the multiple template and clustering methods are more robust to noise due to the smoothing effect of aggregation of correlation scores; and the clustering method results in the best performance in terms of computational efficiency and accuracy.

Original languageEnglish (US)
Article number015
Pages (from-to)741-755
Number of pages15
JournalPhysics in Medicine and Biology
Volume52
Issue number3
DOIs
StatePublished - Feb 7 2007

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Fiducial Markers
Radiotherapy
Computational efficiency
markers
lungs
Tumors
radiation therapy
Lung Neoplasms
templates
Agglomeration
cancer
Radiation
Composite materials
Cluster Analysis
Experiments
Noise
Uncertainty
pneumothorax
Pneumothorax

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Robust fluoroscopic respiratory gating for lung cancer radiotherapy without implanted fiducial markers. / Cui, Ying; Dy, Jennifer G.; Sharp, Greg C.; Alexander, Brian; Jiang, Steve B.

In: Physics in Medicine and Biology, Vol. 52, No. 3, 015, 07.02.2007, p. 741-755.

Research output: Contribution to journalArticle

Cui, Ying ; Dy, Jennifer G. ; Sharp, Greg C. ; Alexander, Brian ; Jiang, Steve B. / Robust fluoroscopic respiratory gating for lung cancer radiotherapy without implanted fiducial markers. In: Physics in Medicine and Biology. 2007 ; Vol. 52, No. 3. pp. 741-755.
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