Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

Denana U. Miodragovic̈; Jeremy A. Quentzel; Josh W. Kurutz; Charlotte L. Stern; Richard W. Ahn; Irawati Kandela; Andrew Mazar; Thomas V. O'Halloran

doi:10.1002/anie.201303251

Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

Denana U. Miodragovic̈, Jeremy A. Quentzel, Josh W. Kurutz, Charlotte L. Stern, Richard W. Ahn, Irawati Kandela, Andrew Mazar, Thomas V. O'Halloran

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The Pt^II-As^III bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.

Original language	English (US)
Pages (from-to)	10749-10752
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	41
DOIs	https://doi.org/10.1002/anie.201303251
State	Published - Oct 4 2013
Externally published	Yes

Keywords

X-ray diffraction
antitumor agents
arsenic
drug design
platinum

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201303251

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title = "Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes",

abstract = "Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The PtII-AsIII bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.",

keywords = "X-ray diffraction, antitumor agents, arsenic, drug design, platinum",

author = "Miodragovi{\"c}, {Denana U.} and Quentzel, {Jeremy A.} and Kurutz, {Josh W.} and Stern, {Charlotte L.} and Ahn, {Richard W.} and Irawati Kandela and Andrew Mazar and O'Halloran, {Thomas V.}",

year = "2013",

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doi = "10.1002/anie.201303251",

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T1 - Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

AU - Miodragovic̈, Denana U.

AU - Quentzel, Jeremy A.

AU - Kurutz, Josh W.

AU - Stern, Charlotte L.

AU - Ahn, Richard W.

AU - Kandela, Irawati

AU - Mazar, Andrew

AU - O'Halloran, Thomas V.

PY - 2013/10/4

Y1 - 2013/10/4

N2 - Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The PtII-AsIII bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.

AB - Anticancer drugs based on molecular adducts of platinum and arsenic (arsenoplatins) show an unanticipated structure, substitution chemistry, and cellular cytotoxicity. The PtII-AsIII bonds in these complexes are stable in aqueous solution and strongly influence the lability of the trans ligand.

KW - X-ray diffraction

KW - antitumor agents

KW - arsenic

KW - drug design

KW - platinum

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U2 - 10.1002/anie.201303251

DO - 10.1002/anie.201303251

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 41

ER -

Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes

Abstract

Keywords

ASJC Scopus subject areas

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