Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α

Dotan Sela, Juliana J. Conkright, Lu Chen, Joshua Gilmore, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan Weliky Conaway

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: ATF6α recruits Mediator to activate endoplasmic reticulum stress response genes. Results: Mediator subunit MED25 contains an ATF6α binding site. Conclusion: The ATF6α-MED25 interaction contributes to Mediator recruitment to genes. Significance: Learning how DNA binding transcription activators recruit coactivators to genes is important for understanding gene regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)26179-26187
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number36
DOIs
StatePublished - Sep 6 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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