Role for rapid dendritic protein synthesis in hippocampal mGluR- dependent long-term depression

Kimberly M. Huber, Matthew S. Kayser, Mark F. Bear

Research output: Contribution to journalArticle

700 Scopus citations

Abstract

A hippocampal pyramidal neuron receives more than 104 excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.

Original languageEnglish (US)
Pages (from-to)1254-1256
Number of pages3
JournalScience
Volume288
Issue number5469
DOIs
StatePublished - May 19 2000

ASJC Scopus subject areas

  • General

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