Role of adenosine in the treatment of myocardial stunning

Mervyn B. Forman, Carlos E. Velasco

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.

Original languageEnglish (US)
Pages (from-to)901-908
Number of pages8
JournalCardiovascular Drugs and Therapy
Volume5
Issue number5
DOIs
StatePublished - Oct 1 1991

Fingerprint

Myocardial Stunning
Adenosine
Adenosine Triphosphate
Ventricular Dysfunction
Regional Blood Flow
Nucleosides
Oxygen Consumption
Free Radicals
Homeostasis
Ischemia
Phosphates
Oxygen
Calcium

Keywords

  • adenosine
  • adenosine triphosphate
  • calcium homeostasis
  • free radicals
  • regional blood flow
  • stunning

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Role of adenosine in the treatment of myocardial stunning. / Forman, Mervyn B.; Velasco, Carlos E.

In: Cardiovascular Drugs and Therapy, Vol. 5, No. 5, 01.10.1991, p. 901-908.

Research output: Contribution to journalArticle

Forman, Mervyn B. ; Velasco, Carlos E. / Role of adenosine in the treatment of myocardial stunning. In: Cardiovascular Drugs and Therapy. 1991 ; Vol. 5, No. 5. pp. 901-908.
@article{2c4421b54ca34f9f85faaf7f470bc521,
title = "Role of adenosine in the treatment of myocardial stunning",
abstract = "Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.",
keywords = "adenosine, adenosine triphosphate, calcium homeostasis, free radicals, regional blood flow, stunning",
author = "Forman, {Mervyn B.} and Velasco, {Carlos E.}",
year = "1991",
month = "10",
day = "1",
doi = "10.1007/BF00053551",
language = "English (US)",
volume = "5",
pages = "901--908",
journal = "Cardiovascular Drugs and Therapy",
issn = "0920-3206",
publisher = "Kluwer Academic Publishers",
number = "5",

}

TY - JOUR

T1 - Role of adenosine in the treatment of myocardial stunning

AU - Forman, Mervyn B.

AU - Velasco, Carlos E.

PY - 1991/10/1

Y1 - 1991/10/1

N2 - Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.

AB - Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.

KW - adenosine

KW - adenosine triphosphate

KW - calcium homeostasis

KW - free radicals

KW - regional blood flow

KW - stunning

UR - http://www.scopus.com/inward/record.url?scp=0025719336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025719336&partnerID=8YFLogxK

U2 - 10.1007/BF00053551

DO - 10.1007/BF00053551

M3 - Article

C2 - 1756136

AN - SCOPUS:0025719336

VL - 5

SP - 901

EP - 908

JO - Cardiovascular Drugs and Therapy

JF - Cardiovascular Drugs and Therapy

SN - 0920-3206

IS - 5

ER -