Abstract
Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 901-908 |
| Number of pages | 8 |
| Journal | Cardiovascular Drugs and Therapy |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 1 1991 |
Keywords
- adenosine
- adenosine triphosphate
- calcium homeostasis
- free radicals
- regional blood flow
- stunning
ASJC Scopus subject areas
- Pharmacology
- Cardiology and Cardiovascular Medicine
- Pharmacology (medical)