Role of adenosine in the treatment of myocardial stunning

Mervyn B. Forman, Carlos E. Velasco

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Adenosine is an endogenous nucleoside produced from the breakdown of adenosine triphosphate (ATP) that possesses a number of complex cellular and metabolic effects that could ameliorate postischemic contractile dysfunction (myocardial stunning). Potential mechanisms include the repletion of high-energy phosphate stores, reduced myocardial oxygen consumption, a decrease in oxygen-derived free radicals, restoration of calcium homeostasis, and an increase in regional myocardial blood flow. Experimental studies have shown that adenosine can reduce myocardial stunning with or without a concomitant increase in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.

Original languageEnglish (US)
Pages (from-to)901-908
Number of pages8
JournalCardiovascular Drugs and Therapy
Volume5
Issue number5
DOIs
StatePublished - Oct 1 1991

Keywords

  • adenosine
  • adenosine triphosphate
  • calcium homeostasis
  • free radicals
  • regional blood flow
  • stunning

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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