Role of adult neurogenesis in hippocampal-cortical memory consolidation

Takashi Kitamura, Kaoru Inokuchi

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision.

Original languageEnglish (US)
Article number13
JournalMolecular brain
Volume7
Issue number1
DOIs
StatePublished - Feb 19 2014

Keywords

  • Hippocampus
  • Neurogenesis
  • Remote memory
  • Synaptic plasticity
  • Systems consolidation

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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