Role of barometric pressure in pulmonary fluid balance and oxygen transport

B. D. Levine, K. Kubo, T. Kobayashi, M. Fukushima, T. Shibamoto, G. Ueda

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

To examine the role of barometric pressure in high-altitude pulmonary edema, we randomly exposed five unanesthetized chronically instrumented sheep with lung lymph fistulas in a decompression chamber to each of three separate conditions: hypobaric hypoxia, normobaric hypoxia, and normoxic hypobaria. A combination of slow decompression and/or simultaneous adjustment of inspired PO2 provided three successive stages of simulated altitudes of 2,600, 4,600, and 6,600 m during which hemodynamics and lymph flow were monitored. Under both hypoxic conditions we noted significant and equivalent elevations in pulmonary arterial pressure (Ppa), cardiac output, and heart rate, with left atrial and systemic pressures remaining fairly constant. Normoxic hypobaria was also accompanied by a smaller but significant rise in Ppa. Lymph flow increased to a highly significant maximum of 73% above base line, accompanied by a slight but significant decrease in lung lymph-to-plasma protein ratio, only under conditions of combined hypobaric hypoxia but not under equivalent degrees of alveolar hypoxia or hypobaria alone. Arterial hypoxemia was noted under all three conditions, with arterial PO2 being uniformly lower under hypobaric conditions than when identical amounts of inspired PO2 were delivered at normal atmospheric pressure. We therefore hypothesize that alveolar pressure significantly alters the Starling forces governing transcapillary fluid flux in the lung and may affect the alveolar-arterial gradient for O2 as well.

Original languageEnglish (US)
Pages (from-to)419-428
Number of pages10
JournalJournal of Applied Physiology
Volume64
Issue number1
StatePublished - 1988

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Water-Electrolyte Balance
Lymph
Oxygen
Pressure
Lung
Decompression
Starlings
Atmospheric Pressure
Atrial Pressure
Pulmonary Edema
Cardiac Output
Fistula
Blood Proteins
Sheep
Arterial Pressure
Heart Rate
Hemodynamics
Hypoxia

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Levine, B. D., Kubo, K., Kobayashi, T., Fukushima, M., Shibamoto, T., & Ueda, G. (1988). Role of barometric pressure in pulmonary fluid balance and oxygen transport. Journal of Applied Physiology, 64(1), 419-428.

Role of barometric pressure in pulmonary fluid balance and oxygen transport. / Levine, B. D.; Kubo, K.; Kobayashi, T.; Fukushima, M.; Shibamoto, T.; Ueda, G.

In: Journal of Applied Physiology, Vol. 64, No. 1, 1988, p. 419-428.

Research output: Contribution to journalArticle

Levine, BD, Kubo, K, Kobayashi, T, Fukushima, M, Shibamoto, T & Ueda, G 1988, 'Role of barometric pressure in pulmonary fluid balance and oxygen transport', Journal of Applied Physiology, vol. 64, no. 1, pp. 419-428.
Levine BD, Kubo K, Kobayashi T, Fukushima M, Shibamoto T, Ueda G. Role of barometric pressure in pulmonary fluid balance and oxygen transport. Journal of Applied Physiology. 1988;64(1):419-428.
Levine, B. D. ; Kubo, K. ; Kobayashi, T. ; Fukushima, M. ; Shibamoto, T. ; Ueda, G. / Role of barometric pressure in pulmonary fluid balance and oxygen transport. In: Journal of Applied Physiology. 1988 ; Vol. 64, No. 1. pp. 419-428.
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