Role of calcineurin in striated muscle: Development, adaptation, and disease

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58 Citations (Scopus)

Abstract

Striated muscles, cardiac and skeletal muscles, use calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium activate calcineurin, a serine/threonine phosphatase, resulting in expression of a set of genes involved in remodeling striated muscle. Activation of calcineurin in hearts produces cardiac hypertrophy, and in skeletal muscle promotes cell differentiation and transforms fiber type specificity. In this review we discuss the effects of calcineurin activity on development, adaptation, and disease of striated muscle.

Original languageEnglish (US)
Pages (from-to)1133-1141
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume311
Issue number4
DOIs
StatePublished - Nov 28 2003

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Striated Muscle
Muscle Development
Calcineurin
Muscle
Skeletal Muscle
Calcium
Phosphoprotein Phosphatases
Cardiomegaly
Second Messenger Systems
Muscle Cells
Cell Differentiation
Myocardium
Genes
Chemical activation
Fibers

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

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