TY - JOUR
T1 - Role of carnitine in hepatic ketogenesis
AU - McGarry, J. D.
AU - Robles Valdes, C.
AU - Foster, D. W.
PY - 1975
Y1 - 1975
N2 - The enhancement of long chain fatty acid oxidation and ketogenesis in the perfused rat liver, whether induced acutely by treatment of fed animals with anti insulin serum or glucagon, or over the longer term by starvation or the induction of alloxan diabetes, was found to be accompanied by a proportional elevation in the tissue carnitine content. Moreover, when added to the medium perfusing livers from fed rats, carnitine stimulated ketogenesis from oleic acid. The findings suggest, that the increased fatty acid flux through the carnitine acyltransferase (carnitine palmitoyltransferase; palmitoyl CoA:L carnitine O palmitoyltransferase; EC 2.3.1.21) reaction brought about by glucagon excess, with or without insulin deficiency, is mediated, at least in part, by elevation in the liver carnitine concentration.
AB - The enhancement of long chain fatty acid oxidation and ketogenesis in the perfused rat liver, whether induced acutely by treatment of fed animals with anti insulin serum or glucagon, or over the longer term by starvation or the induction of alloxan diabetes, was found to be accompanied by a proportional elevation in the tissue carnitine content. Moreover, when added to the medium perfusing livers from fed rats, carnitine stimulated ketogenesis from oleic acid. The findings suggest, that the increased fatty acid flux through the carnitine acyltransferase (carnitine palmitoyltransferase; palmitoyl CoA:L carnitine O palmitoyltransferase; EC 2.3.1.21) reaction brought about by glucagon excess, with or without insulin deficiency, is mediated, at least in part, by elevation in the liver carnitine concentration.
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U2 - 10.1073/pnas.72.11.4385
DO - 10.1073/pnas.72.11.4385
M3 - Article
C2 - 1060116
AN - SCOPUS:0001354342
SN - 0027-8424
VL - 72
SP - 4385
EP - 4388
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -