Role of Cdk5 in drug abuse and plasticity

David R. Benavides, James A. Bibb

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neuronal plasticity serves as the basis for learning and memory in the adult brain. Contextual, motor, and reward-based learning are important in reinforcing survival behavior in animals. Most psychostimulant drugs of abuse target the dopaminergic reward system of the brain. Drugs of abuse cause long-standing cellular and molecular neuroadaptations in the brain. The neuronal protein kinase Cdk5 is emerging as an important player in the cellular and physiological responses to drugs of abuse. Substantial evidence indicates that Cdk5 controls dopamine neurotransmission through regulation of the protein phosphatase-1 inhibitor, DARPP-32. Furthermore, the morphological changes associated with chronic cocaine exposure are dependent on Cdk5. Thus, Cdk5 mediates cellular responses to psychostimulant drug-induced changes in dopamine signal transduction and cytoskeletal reorganization. In this regard, Cdk5, through its targeting of various substrates, integrates a number of intracellular pathways that are targeted by psychostimulant drugs. These studies and the emerging role of Cdk5 in various forms of neuronal plasticity are reviewed.

Original languageEnglish (US)
Pages (from-to)335-344
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume1025
DOIs
StatePublished - 2004

Fingerprint

Street Drugs
Substance-Related Disorders
Plasticity
Brain
Neuronal Plasticity
Reward
Dopamine
Cyclin-Dependent Kinase 5
Learning
Pharmaceutical Preparations
Signal transduction
Animal Behavior
Cocaine
Synaptic Transmission
Signal Transduction
Animals
Data storage equipment
Substrates
Abuse
Drugs

Keywords

  • Cdk5
  • Drug addiction
  • Neuronal plasticity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Role of Cdk5 in drug abuse and plasticity. / Benavides, David R.; Bibb, James A.

In: Annals of the New York Academy of Sciences, Vol. 1025, 2004, p. 335-344.

Research output: Contribution to journalArticle

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