Role of central command in carotid baroreflex resetting in humans during static exercise

S. Ogoh, W. L. Wasmund, D. M. Keller, A. O. Yurvati, K. M. Gallagher, J. H. Mitchell, P. B. Raven

Research output: Contribution to journalArticle

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Abstract

The purpose of the experiments was to examine the role of central command in the exercise-induced resetting of the carotid baroreflex. Eight subjects performed 30% maximal voluntary contraction (MVC) static knee extension and flexion with manipulation of central command (CC) by patellar tendon vibration (PTV). The same subjects also performed static knee extension and flexion exercise without PTV at a force development that elicited the same ratings of perceived exertion (RPE) as those observed during exercise with PTV in order to assess involvement of the exercise pressor reflex. Carotid baroreflex (CBR) function curves were modelled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid changes in neck pressure and suction during steady state static exercise. Knee extension exercise with PTV (decreased CC activation) reset the CBR-HR and CBR-MAP to a lower operating pressure (P < 0.05) and knee flexion exercise with PTV (increased CC activation) reset the CBR-HR and CBR-MAP to a higher operating pressure (P < 0.05). Comparison between knee extension and flexion exercise at the same RPE with and without PTV found no difference in the resetting of the CBR-HR function curves (P > 0.05) suggesting the response was determined primarily by CC activation. However, the CBR-MAP function curves were reset to operating pressures determined by both exercise pressor reflex (EPR) and central command activation. Thus the physiological response to exercise requires CC activation to reset the carotid-cardiac reflex but requires either CC or EPR to reset the carotid-vasomotor reflex.

Original languageEnglish (US)
Pages (from-to)349-364
Number of pages16
JournalJournal of Physiology
Volume543
Issue number1
DOIs
StatePublished - Aug 15 2002

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Baroreflex
Patellar Ligament
Reflex
Vibration
Knee
Arterial Pressure
Pressure
Heart Rate
Suction
Neck

ASJC Scopus subject areas

  • Physiology

Cite this

Ogoh, S., Wasmund, W. L., Keller, D. M., Yurvati, A. O., Gallagher, K. M., Mitchell, J. H., & Raven, P. B. (2002). Role of central command in carotid baroreflex resetting in humans during static exercise. Journal of Physiology, 543(1), 349-364. https://doi.org/10.1113/jphysiol.2002.019943

Role of central command in carotid baroreflex resetting in humans during static exercise. / Ogoh, S.; Wasmund, W. L.; Keller, D. M.; Yurvati, A. O.; Gallagher, K. M.; Mitchell, J. H.; Raven, P. B.

In: Journal of Physiology, Vol. 543, No. 1, 15.08.2002, p. 349-364.

Research output: Contribution to journalArticle

Ogoh, S, Wasmund, WL, Keller, DM, Yurvati, AO, Gallagher, KM, Mitchell, JH & Raven, PB 2002, 'Role of central command in carotid baroreflex resetting in humans during static exercise', Journal of Physiology, vol. 543, no. 1, pp. 349-364. https://doi.org/10.1113/jphysiol.2002.019943
Ogoh, S. ; Wasmund, W. L. ; Keller, D. M. ; Yurvati, A. O. ; Gallagher, K. M. ; Mitchell, J. H. ; Raven, P. B. / Role of central command in carotid baroreflex resetting in humans during static exercise. In: Journal of Physiology. 2002 ; Vol. 543, No. 1. pp. 349-364.
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