Role of endothelial cells in early pancreas and liver development

Eckhard Lammert; Ondine Cleaver; Douglas Melton

doi:10.1016/S0925-4773(02)00332-5

Role of endothelial cells in early pancreas and liver development

Eckhard Lammert, Ondine Cleaver, Douglas Melton

Research output: Contribution to journal › Review article › peer-review

227 Scopus citations

Abstract

Liver and pancreas initially develop by budding from the embryonic endoderm. The formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent to the endoderm. ECs either develop in situ in organs, or are recruited by organs and are induced to form blood vessels. Recent reports on liver and pancreas have now shown that ECs also induce essential steps in organ formation such as morphogenesis and cell differentiation. This review summarizes reports on EC signaling during organogenesis and cell differentiation.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Mechanisms of Development
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/S0925-4773(02)00332-5
State	Published - Jan 2003

Keywords

Blood vessel
Differentiation
Endothelial cell
Kidney
Liver
Morphogenesis
Neuron
Organogenesis
Pancreas

ASJC Scopus subject areas

Embryology
Developmental Biology

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10.1016/S0925-4773(02)00332-5

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title = "Role of endothelial cells in early pancreas and liver development",

abstract = "Liver and pancreas initially develop by budding from the embryonic endoderm. The formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent to the endoderm. ECs either develop in situ in organs, or are recruited by organs and are induced to form blood vessels. Recent reports on liver and pancreas have now shown that ECs also induce essential steps in organ formation such as morphogenesis and cell differentiation. This review summarizes reports on EC signaling during organogenesis and cell differentiation.",

keywords = "Blood vessel, Differentiation, Endothelial cell, Kidney, Liver, Morphogenesis, Neuron, Organogenesis, Pancreas",

author = "Eckhard Lammert and Ondine Cleaver and Douglas Melton",

note = "Funding Information: We thank C. Anneren, J. Brown and C. Murtaugh for critical comments. E. L. was supported by the Deutsche Forschungsgemeinschaft (La 1216/1-1) and the American Diabetes Association, O. C. was supported by the Cancer Research Fund of the Damon Runyon -Walter Winchell Foundation Fellowship (DRG 1534), and D. M. is an investigator of the Howard Hughes Medical Institute.",

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T1 - Role of endothelial cells in early pancreas and liver development

AU - Lammert, Eckhard

AU - Cleaver, Ondine

AU - Melton, Douglas

N1 - Funding Information: We thank C. Anneren, J. Brown and C. Murtaugh for critical comments. E. L. was supported by the Deutsche Forschungsgemeinschaft (La 1216/1-1) and the American Diabetes Association, O. C. was supported by the Cancer Research Fund of the Damon Runyon -Walter Winchell Foundation Fellowship (DRG 1534), and D. M. is an investigator of the Howard Hughes Medical Institute.

PY - 2003/1

Y1 - 2003/1

N2 - Liver and pancreas initially develop by budding from the embryonic endoderm. The formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent to the endoderm. ECs either develop in situ in organs, or are recruited by organs and are induced to form blood vessels. Recent reports on liver and pancreas have now shown that ECs also induce essential steps in organ formation such as morphogenesis and cell differentiation. This review summarizes reports on EC signaling during organogenesis and cell differentiation.

AB - Liver and pancreas initially develop by budding from the embryonic endoderm. The formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent to the endoderm. ECs either develop in situ in organs, or are recruited by organs and are induced to form blood vessels. Recent reports on liver and pancreas have now shown that ECs also induce essential steps in organ formation such as morphogenesis and cell differentiation. This review summarizes reports on EC signaling during organogenesis and cell differentiation.

KW - Blood vessel

KW - Differentiation

KW - Endothelial cell

KW - Kidney

KW - Liver

KW - Morphogenesis

KW - Neuron

KW - Organogenesis

KW - Pancreas

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DO - 10.1016/S0925-4773(02)00332-5

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AN - SCOPUS:0037212977

SN - 0925-4773

VL - 120

SP - 59

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JO - Mechanisms of Development

JF - Mechanisms of Development

IS - 1

ER -

Role of endothelial cells in early pancreas and liver development

Abstract

Keywords

ASJC Scopus subject areas

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