TY - JOUR
T1 - Role of Extracellular Vesicles in the Diagnosis and Pathogenesis of Barrett’s Esophagus
T2 - A Mini-Review
AU - Zhang, Qiuyang
AU - Bansal, Ajay
N1 - Funding Information:
This project was supported by a clinical research grant from the American College of Gastroenterology. The content is solely the responsibility of the authors. The funders had no role in data generation or preparation of the manuscript. Acknowledgment
Funding Information:
We would like to thank Rhonda Souza, Co-Director, Center for Esophageal Diseases, Baylor University Medical Center at Dallas, Dallas, TX and Dan Dixon, Associate Professor of Molecular Biosciences, Co-Leader Drug Discovery, Delivery and Experimental Therapeutics Program, University of Kansas Cancer Center, Kansas City, KS for their thorough read of the article and their critical input.
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/3
Y1 - 2021/3
N2 - Esophageal adenocarcinoma (EAC) continues to be a significant public health problem with survival rates that have remained stagnant. Although the population at the highest risk for EAC, i.e., patients with Barrett’s esophagus (BE) has been clearly defined, patients with EAC continue to do poorly due to advanced stage at diagnosis. The field of extracellular vesicles (EV) could have huge application for the management of patients with BE and EAC by allowing timely diagnosis, serial monitoring, and improved understanding of disease biology. EV are actively packaged and actively secreted vesicles and contain microRNAs, proteins, lipids, and DNA. The contents of EV have been shown to provide useful insights into cellular transformation and pro-oncogenic processes. Early work shows promise but suffers from a high degree of technical and biological variation. The current review not only summarizes the current knowledge about EV as diagnostic biomarkers and their role in disease progression of BE and EAC but also provides the reader practical guidance to devise future experiments to perform well-designed studies.
AB - Esophageal adenocarcinoma (EAC) continues to be a significant public health problem with survival rates that have remained stagnant. Although the population at the highest risk for EAC, i.e., patients with Barrett’s esophagus (BE) has been clearly defined, patients with EAC continue to do poorly due to advanced stage at diagnosis. The field of extracellular vesicles (EV) could have huge application for the management of patients with BE and EAC by allowing timely diagnosis, serial monitoring, and improved understanding of disease biology. EV are actively packaged and actively secreted vesicles and contain microRNAs, proteins, lipids, and DNA. The contents of EV have been shown to provide useful insights into cellular transformation and pro-oncogenic processes. Early work shows promise but suffers from a high degree of technical and biological variation. The current review not only summarizes the current knowledge about EV as diagnostic biomarkers and their role in disease progression of BE and EAC but also provides the reader practical guidance to devise future experiments to perform well-designed studies.
KW - Barrett’s esophagus
KW - Esophageal adenocarcinoma
KW - Exosomes
KW - Extracellular vesicles
KW - microRNA
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U2 - 10.1007/s10620-020-06250-1
DO - 10.1007/s10620-020-06250-1
M3 - Review article
C2 - 32277372
AN - SCOPUS:85083107393
SN - 0163-2116
VL - 66
SP - 705
EP - 713
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 3
ER -