Role of HLA-B and C alleles in development of psoriasis in patients from North India

R. Rani, R. Narayan, M. A. Fernandez-Vina, P. Stastny

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The association of HLA antigens with susceptibility for development of psoriasis vulgaris has been studied mostly using serologic methods. A number of different HLA class I antigens have been reported to be associated with predisposition to develop this disease. While Cw6 is the allele most commonly thought to confer risk for psoriasis, a number of HLA-B locus alleles have also been thought to be involved and, recently, in at least three studies, a specific amino acid in the HLA-C heavy chain has been implicated. With the recent development of molecular methods for typing for HLA class I alleles, it has become possible to re-examine this association by performing high resolution typing. In the present study we have investigated 38 psoriasis patients and 84 ethnically and geographically matched controls from North India. They were typed for HLA-B and HLA-C. The results showed the Cw*0602 was the main allele that was increased in this group of patients. The previously reported association with alanine-73 was not found to be significant. Cw*0602 was found in 71% of the patients. B*5701 and B*3701 were also increased but appeared to be secondary to linkage disequilibrium with Cw*0602.

Original languageEnglish (US)
Pages (from-to)618-622
Number of pages5
JournalTissue Antigens
Volume51
Issue number6
StatePublished - 1998

Fingerprint

HLA-C Antigens
HLA-B Antigens
Psoriasis
India
Alleles
HLA Antigens
Molecular Typing
Histocompatibility Antigens Class I
Linkage Disequilibrium
Alanine
Amino Acids

Keywords

  • HLA antigens
  • PCR-SSOP
  • Psoriasis vulgaris

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Rani, R., Narayan, R., Fernandez-Vina, M. A., & Stastny, P. (1998). Role of HLA-B and C alleles in development of psoriasis in patients from North India. Tissue Antigens, 51(6), 618-622.

Role of HLA-B and C alleles in development of psoriasis in patients from North India. / Rani, R.; Narayan, R.; Fernandez-Vina, M. A.; Stastny, P.

In: Tissue Antigens, Vol. 51, No. 6, 1998, p. 618-622.

Research output: Contribution to journalArticle

Rani, R, Narayan, R, Fernandez-Vina, MA & Stastny, P 1998, 'Role of HLA-B and C alleles in development of psoriasis in patients from North India', Tissue Antigens, vol. 51, no. 6, pp. 618-622.
Rani R, Narayan R, Fernandez-Vina MA, Stastny P. Role of HLA-B and C alleles in development of psoriasis in patients from North India. Tissue Antigens. 1998;51(6):618-622.
Rani, R. ; Narayan, R. ; Fernandez-Vina, M. A. ; Stastny, P. / Role of HLA-B and C alleles in development of psoriasis in patients from North India. In: Tissue Antigens. 1998 ; Vol. 51, No. 6. pp. 618-622.
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AB - The association of HLA antigens with susceptibility for development of psoriasis vulgaris has been studied mostly using serologic methods. A number of different HLA class I antigens have been reported to be associated with predisposition to develop this disease. While Cw6 is the allele most commonly thought to confer risk for psoriasis, a number of HLA-B locus alleles have also been thought to be involved and, recently, in at least three studies, a specific amino acid in the HLA-C heavy chain has been implicated. With the recent development of molecular methods for typing for HLA class I alleles, it has become possible to re-examine this association by performing high resolution typing. In the present study we have investigated 38 psoriasis patients and 84 ethnically and geographically matched controls from North India. They were typed for HLA-B and HLA-C. The results showed the Cw*0602 was the main allele that was increased in this group of patients. The previously reported association with alanine-73 was not found to be significant. Cw*0602 was found in 71% of the patients. B*5701 and B*3701 were also increased but appeared to be secondary to linkage disequilibrium with Cw*0602.

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