Role of inhibitors of mammalian target of rapamycin in the treatment of luminal breast cancer

Eva Ciruelos, Hernán Cortes-Funes, Ismael Ghanem, Luis Manso, Carlos Arteaga

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Approximately 75% of patients with breast cancer present hormone receptor-positive tumors. This subtype of breast cancer initially shows a high overall response rate to hormonal treatments. However, resistance eventually develops, resulting in tumor progression. The PI3K/Akt/mTOR pathway regulates several cellular functions in cancer such as cell growth, survival, and proliferation. In addition, a high activation level of the PI3K/Akt/mTOR pathway is related to resistance to conventional chemotherapy and hormone therapy. The mTOR inhibitor everolimus, in combination with hormonal treatments, has led to excellent results in progression-free survival in patients with metastatic breast cancer resistant to hormone therapies. Therefore, everolimus has entered the National Comprehensive Cancer Network (NCCN) guidelines 2012 and its combination with exemestane was approved recently by the US Food and Drug Administration and the European Medicines Agency. This is the first time that a drug will have been approved for the restoration of hormone sensitivity in breast cancer.

Original languageEnglish (US)
Pages (from-to)769-780
Number of pages12
JournalAnti-Cancer Drugs
Volume24
Issue number8
DOIs
Publication statusPublished - Sep 1 2013

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Keywords

  • breast cancer
  • estrogen receptor
  • everolimus
  • human epidermal growth factor receptor 2
  • mammalian target of rapamycin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research
  • Oncology

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