Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

Virginia Pascual, Florence Allantaz, Edsel Arce, Marilynn Punaro, Jacques Banchereau

Research output: Contribution to journalArticle

657 Scopus citations

Abstract

Systemic onset juvenile idiopathic arthritis (SoJIA) encompasses ≃10% of cases of arthritis that begin in childhood. The disease is unique in terms of clinical manifestations, severity of joint involvement, and lack of response to tumor necrosis factor blockade. Here, we show that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs). Upon activation, SoJIA PBMCs release large amounts of IL-1β. We administered recombinant IL-1 receptor antagonist to nine SoJIA patients who were refractory to other therapies. Complete remission was obtained in seven out of nine patients and a partial response was obtained in the other two patients. We conclude that IL-1 is a major mediator of the inflammatory cascade that underlies SoJIA and that this cytokine represents a target for therapy in this disease.

Original languageEnglish (US)
Pages (from-to)1479-1486
Number of pages8
JournalJournal of Experimental Medicine
Volume201
Issue number9
DOIs
StatePublished - May 2 2005

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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